The coming of age of chaperone-mediated autophagy.
The coming of age of chaperone-mediated autophagy.
复制标题
伴侣介导的自噬的时代的到来。
DOI：
10.1038/s41580-018-0001-6
复制
发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Cuervo AM
中科院分区：
文献类型：
--
作者：
Kaushik S;Cuervo AM
伴侣介导的自噬(CMA)是第一个表明溶酶体可以选择性地降解细胞内成分的研究过程--这个概念现在已经被其他形式的自噬很好地接受。溶酶体能以一种非特异性的方式降解细胞胞浆，但也可以通过降解标签、伴侣和复杂的机制来区分降解的靶点，使选定的蛋白质通过专门的易位复合体穿过溶酶体膜。最近利用转基因小鼠模型在体内调节CMA活性的研究表明，选择性赋予CMA参与多种细胞功能调节的能力。CMA能及时降解特定的细胞蛋白质，调节糖脂代谢、DNA修复、细胞重编程和细胞对应激的反应。这些发现扩大了CMA在蛋白质质量控制中的生理意义，并揭示了CMA随着年龄的增长而失效可能会加重疾病，如与衰老相关的神经退化和癌症。
Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the lysosome can be selective — a concept that is now well accepted for other forms of autophagy. Lysosomes can degrade cellular cytosol in a nonspecific manner but can also discriminate what to target for degradation with the involvement of a degradation tag, a chaperone and a sophisticated mechanism to make the selected proteins cross the lysosomal membrane through a dedicated translocation complex. Recent studies modulating CMA activity in vivo using transgenic mouse models have demonstrated that selectivity confers on CMA the ability to participate in the regulation of multiple cellular functions. Timely degradation of specific cellular proteins by CMA modulates, for example, glucose and lipid metabolism, DNA repair, cellular reprograming and the cellular response to stress. These findings expand the physiological relevance of CMA beyond its originally identified role in protein quality control and reveal that CMA failure with age may aggravate diseases, such as ageing-associated neurodegeneration and cancer.
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DOI：
10.1083/jcb.137.4.825
发表时间：
1997-05-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Agarraberes FA;Terlecky SR;Dice JF
通讯作者：
Dice JF
影响因子：
5.3
作者：
Bandyopadhyay, Urmi;Kaushik, Susmita;Cuervo, Ana Maria
通讯作者：
Cuervo, Ana Maria
影响因子：
6
作者：
Cai, Yan;Jogasuria, Alvin;You, Min
通讯作者：
You, Min
影响因子：
56.9
作者：
CHIANG, HL;TERLECKY, SR;DICE, JF
通讯作者：
DICE, JF
影响因子：
11.4
作者：
Cuervo, AM;Mann, L;Dice, JF
通讯作者：
Dice, JF