Alternative therapies for bipolar disorder.
Alternative therapies for bipolar disorder.
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双相情感障碍的替代疗法。
DOI：
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发表时间：
1985
影响因子：
5.3
通讯作者：
B. Lerer
中科院分区：
文献类型：
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作者：
B. Lerer
锂在治疗躁狂抑郁症方面的成功突出了少数双相情感障碍患者所带来的问题，这些患者是锂无反应者或遭受严重不良反应。已经提出了一些可能的替代治疗方法，并评估了支持其临床疗效的证据。目前，只有抗惊厥药卡马西平可被视为临床上可应用的锂的潜在替代品。在卡马西平的抗躁狂和预防作用被最终确定之前，还需要进一步的对照研究。其他治疗方法具有相当大的理论意义和潜在的临床价值，但需要进行更彻底的评估。
The success of lithium in the treatment of manic-depressive illness has highlighted the problems posed by the minority of bipolar patients who are lithium nonresponders or who suffer severe adverse effects. A number of possible alternative treatments have been proposed, and the evidence in support of their clinical efficacy is evaluated. At this time, only the anticonvulsant carbamazepine can be regarded as a clinically applicable potential alternative to lithium. Further controlled studies are needed before the antimanic and prophylactic efficacy of carbamazepine can be regarded as conclusively established. Other treatment approaches are of considerable theoretical interest and of potential value clinically but need to be more thoroughly evaluated.