Effect of a Low Sodium Diet on Aldosterone-Stimulating Activity Of Angiotensin II in Dogs
Effect of a Low Sodium Diet on Aldosterone-Stimulating Activity Of Angiotensin II in Dogs
复制标题
低钠饮食对狗血管紧张素 II 醛固酮刺激活性的影响
DOI：
10.3181/00379727-124-31973
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发表时间：
1967
影响因子：
--
通讯作者：
A. Boryczka
中科院分区：
文献类型：
--
作者：
W. F. Ganong;A. Boryczka
本文测定了不同剂量的血管紧张素II对喂食低钠饮食14天的犬和对照组犬肾上腺皮质分泌醛固酮和17-羟基皮质激素的影响。在喂食低钠饮食的动物中，血管紧张素II产生的醛固酮分泌的增量大于对照组的相应增量。未观察到17-羟基皮质激素增量和血压的变化。血管紧张素II(1-L-天冬酰胺-5-L-八肽)由汽巴制药公司提供，N.J.ACTH由Upjohn公司提供，Lonalac由美赞臣公司提供，感谢Roy Shackelford先生和玛格丽特·萨里小姐的技术帮助。
Summary The effect of various doses of angiotensin II on adrenocortical secretion of aldosterone and 17-hydroxycorticoids was determined in dogs fed a low sodium diet for 14 days and in control dogs. The increments in aldosterone secretion produced by angiotensin II in the animals fed the low sodium diet were greater than the corresponding increments in controls. No changes in the increments in 17-hydroxycorticoids or blood pressure were observed. Angiotensin II (1-L-asparaginyl-5-L-valyl angiotensin octapeptide) was provided by Ciba Pharmaceutical Co., Summit, N. J. ACTH was provided by Upjohn Co., and Lonalac for preparation of low sodium diets by Mead Johnson Co. We wish to thank Mr. Roy Shackelford and Miss Margaret Saari for technical assistance.