Evolution of COVID-19 in patients with autoimmune rheumatic diseases.
Evolution of COVID-19 in patients with autoimmune rheumatic diseases.
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DOI：
10.18632/aging.202193
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发表时间：
2020-12-03
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Pang R;Zhao J;Gan Z;Hu Z;Xue X;Wu Y;Qiao Q;Zhong A;Xia X;Liao H;Wang Z;Zhang L
新冠肺炎患者合并自身免疫性风湿病(AID)的特点鲜有报道。呼吸道疾病患者免疫防御功能受到抑制，这可能增加他们对新冠肺炎的易感性。然而，患者常规使用的免疫抑制剂可能有利于保护SARS-CoV-2引起的细胞因子风暴。在这项回顾性研究中，我们纳入了2月4日至4月9日在霍神山医院确诊的所有病例。数据从电子病历中提取，并使用SPSS(版本25.0)对临床和实验室特征进行分析。3059例患者中，21例合并系统性红斑狼疮(SLE)和/或类风湿关节炎(RA)，其中SLE 5例，RA 15例，大黄1例。危重病例占57.1%，危重或危重病例占61.9%，危重病例占4.8%。新冠肺炎在急性呼吸窘迫综合征患者中的主要表现、急性呼吸窘迫综合征和ICU住院率、病死率和住院时间与普通人群中的新冠肺炎患者相似。我们的初步经验表明，患有Aird的患者倾向于有更高的SARS-CoV-2感染风险，并可能面临严重但不太可能出现危重病程的风险。要了解这些疾病的免疫学特征还需要进一步的研究。
The characteristics of COVID-19 patients with autoimmune rheumatic diseases (AIRD) have rarely been reported. Patients with AIRD have suppressed immune defense function, which may increase their susceptibility to COVID-19. However, the immunosuppressive agents AIRD patients routinely used may be beneficial for protecting the cytokine storm caused by SARS-CoV-2. In this retrospective study, we included all confirmed cases in Huoshenshan Hospital from February 4 to April 9. Data were extracted from electronic medical records and were analyzed for clinical and laboratory features using SPSS (version 25.0). Of 3059 patients, 21 had the comorbidities with systematic lupus erythematosus (SLE) and/or rheumatoid arthritis (RA), including 5 with SLE, 15 with RA, and 1 with Rhupus. The proportion was 57.1% for severe cases, 61.9% for either severe or critical cases, and 4.8% for critical cases. The main manifestations, ARDS and ICU admission rate, as well as the mortality and length of hospital stay of COVID-19 in AIRD patients were similar to COVID-19 patients in the general population. Our preliminary experience shows that patients with AIRD tend to have a higher risk of SARS-CoV-2 infection, and may be at risk for a severe but less likely critical disease course. Further investigation is needed to understand the immunological features of these diseases.
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影响因子：
1.7
作者：
Gomides A;Ferreira G;Kakehasi A;Lacerda M;Marques C;Mota L;Paiva E;Pileggi G;Provenza J;Reis-Neto E;Sampaio V;Xavier R;Pinheiro M
通讯作者：
Pinheiro M
影响因子：
5
作者：
Kilian A;Chock YP;Huang IJ;Graef ER;Upton LA;Khilnani A;Krupnikova SDS;Almaghlouth I;Cappelli LC;Fernandez-Ruiz R;Frankel BA;Frankovich J;Harrison C;Kumar B;Monga K;Vega JAR;Singh N;Sparks JA;Sullo E;Young KJ;Duarte-Garcia A;Putman M;Johnson S;Grainger R;Wallace ZS;Liew JW;Jayatilleke A
通讯作者：
Jayatilleke A
影响因子：
4.9
作者：
Zeng QY;Chen R;Darmawan J;Xiao ZY;Chen SB;Wigley R;Le Chen S;Zhang NZ
通讯作者：
Zhang NZ
DOI：
10.1016/j.jinf.2004.09.008
发表时间：
2005-08
期刊：
The Journal of infection
影响因子：
--
作者：
Auyeung TW;Lee JS;Lai WK;Choi CH;Lee HK;Lee JS;Li PC;Lok KH;Ng YY;Wong WM;Yeung YM
通讯作者：
Yeung YM
影响因子：
158.5
作者：
Guan, W.;Ni, Z.;Zhong, N.
通讯作者：
Zhong, N.