Agent-specific ras oncogene activation in rat thyroid tumours.
Agent-specific ras oncogene activation in rat thyroid tumours.
复制标题
大鼠甲状腺肿瘤中药物特异性 ras 癌基因激活。
作者：
Nicholas R. Lemoine;E. Mayall;E. Williams;Thurston;D. Wynford
已经在许多啮齿动物肿瘤模型系统中检测到激活的ras癌基因（巴尔曼等人，1986; Barbacid 1987），其中化学致癌物是最广泛使用的诱导剂。我们已经调查了参与激活癌基因在一个单一的特征肿瘤模型，大鼠甲状腺肿瘤，不仅产生的化学致癌物（亚硝基甲基脲，NMU）和电离辐射，但也升高营养刺激单独。我们已经确定了一个惊人的特异性ras癌基因激活的模式，专门Ha-ras激活87%的NMU诱导的肿瘤和专门Ki-ras激活60%的辐射诱导的肿瘤。
Activated ras oncogenes have been detected in a number of rodent tumour model systems (Balmain et al., 1986; Barbacid 1987), in which chemical carcinogens have been the most widely used inducing agents. We have investigated the involvement of activated oncogenes in a single well-characterised tumour model, rat thyroid neoplasia, produced not only by chemical carcinogen (nitrosomethylurea, NMU) and by ionizing radiation but also by elevated trophic stimulation alone. We have indentified a striking specificity in patterns of ras oncogene activation, with exclusively Ha-ras activated in 87% of NMU-induced tumours and exclusively Ki-ras activated in 60% of radiation-induced tumours.