Evaluation of ventriculomegaly using diffusion tensor imaging: correlations with chronic hydrocephalus and atrophy Clinical article
Evaluation of ventriculomegaly using diffusion tensor imaging: correlations with chronic hydrocephalus and atrophy Clinical article
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DOI：
10.3171/2009.7.jns09550
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发表时间：
2010-04-01
影响因子：
4.1
通讯作者：
Matsumura, Akira
中科院分区：
文献类型：
--
作者：
Osuka, Satoru;Matsushita, Akira;Matsumura, Akira
Object.巨结肠是一种常见的成像发现在许多类型的条件。在外伤、中风或感染性疾病后，仅使用成像程序（如MR成像）难以确定其是否与真正的脑积水或萎缩过程相关。扩散张量（DT）成像可以区分白色物质的压缩特征，表明扩散各向异性增加可能与白色物质压缩有关。在这项初步研究中，作者比较了脑室扩大与慢性脑积水或萎缩的DT成像结果，以阐明弥散各向异性在识别脑积水中的潜力。10例慢性脑积水患者、8例萎缩患者（由传统器械和手术结果定义）和14例健康志愿者接受了DT成像。在分流前后采集图像，或在无分流的情况下采集一次图像。测量侧脑室周围各点的各向异性分数（FA）。慢性脑积水组和萎缩组侧脑室周围FA图形不同。尤其是在尾状核。与脑萎缩组相比，慢性脑积水组FA增加。此外，FA值在分流器放置后恢复到正常水平。尾状核FA值的评估可能是一个重要的，微创的方法来区分真正的脑积水脑室扩大。需要在大量患者中进行进一步研究，以验证该方法的诊断能力。(DOI：10.3171/2009.7.JNS09550）
Object. Ventriculomegaly is a common imaging finding in many types of conditions. It is difficult to determine whether it is related to true hydrocephalus or to an atrophic process by using only imaging procedures such as MR imaging after traumatic injury, stroke, or infectious disease. Diffusion tensor (DT) imaging can distinguish the compression characteristics of white matter, indicating that increased diffusion anisotropy may be related to white matter compression. In this preliminary study, the authors compared the DT imaging findings of ventriculomegaly with those of chronic hydrocephalus or atrophy to clarify the potential of diffusion anisotropy in the identification of hydrocephalus.Methods. Ten patients with chronic hydrocephalus, 8 patients with atrophy (defined by conventional devices and surgical outcome), and 14 healthy volunteers underwent DT imaging. Images were acquired before and after shunting or once in cases without shunting. The fractional anisotropy (FA) values at many points around the lateral ventricle were evaluated.Results. The FA patterns around the lateral ventricle in the chronic hydrocephalus and atrophy groups were different. Especially in the caudate nucleus. FA was increased in the chronic hydrocephalus group compared with the atrophy group. Furthermore, the FA values returned to normal levels after shunt placement.Conclusions. Assessment of the FA value of the caudate nucleus may be an important, less invasive method for distinguishing true hydrocephalus from ventriculomegaly. Further research in a large number of patients is needed to verify the diagnostic ability of this method. (DOI: 10.3171/2009.7.JNS09550)