Identification and evolution of the orphan genes in the domestic silkworm,Bombyx mori
Identification and evolution of the orphan genes in the domestic silkworm,Bombyx mori
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DOI：
10.1016/j.febslet.2015.08.008
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发表时间：
2015-09
期刊：
影响因子：
3.5
通讯作者：
Wei Sun;Xin-Wei Zhao;Ze Zhang
中科院分区：
文献类型：
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作者：
Wei Sun;Xin-Wei Zhao;Ze Zhang
孤儿基因（OGs）与其他物种的任何序列没有可识别的同源性，可能有助于物种的特异性适应。在这项研究中，我们鉴定了家蚕基因组中的738个OGs。家蚕基因序列中约有31%来自转座因子，5.1%来自基因复制后的同源分化。五种新蚕的og起源于非编码区。微阵列数据显示，大多数家蚕OGs在有限的组织中表达。RNA干扰实验表明，这五种新基因对家蚕来说并不是必需的，这意味着它们可能有助于遗传冗余或物种特异性适应。我们的研究结果为家蚕OGs的进化意义提供了一些新的见解。
Orphan genes (OGs) which have no recognizable homology to any sequences in other species could contribute to the species specific adaptations. In this study, we identified 738 OGs in the silkworm genome. About 31% of the silkworm OGs is derived from transposable elements, and 5.1% of the silkworm OGs emerged from gene duplication followed by divergence of paralogs. Fivede novosilkworm OGs originated from non-coding regions. Microarray data suggested that most of the silkworm OGs were expressed in limited tissues. RNA interference experiments suggested that fivede novoOGs are not essential to the silkworm, implying that they may contribute to genetic redundancy or species-specific adaptation. Our results provide some new insights into the evolutionary significance of the silkworm OGs.