Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood - The Bogalusa Heart Study
Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood - The Bogalusa Heart Study
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DOI：
10.2337/diabetes.51.1.204
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发表时间：
2002-01-01
期刊：
影响因子：
7.7
通讯作者：
Berenson, GS
中科院分区：
文献类型：
--
作者：
Srinivasan, SR;Myers, L;Berenson, GS
胰岛素抵抗综合征（X综合征）的发生在一般人群中很常见。然而，关于X综合征的儿童预测因子的信息很少。本研究在一个以社区为基础的纵向队列研究中（n = 745;基线年龄，8-17岁;平均+/- SD随访期，11.6 +/- 3.4年），检查了儿童肥胖和胰岛素对成年后发生X综合征风险的相对贡献。考虑的四个标准风险变量是1）BMI，2）空腹胰岛素，3）收缩压或平均动脉压和4）总胆固醇与HDL胆固醇比值或甘油三酯与HDL胆固醇比值的最高四分位数（具体针对年龄，种族，性别和研究年份）。聚类被定义为所有四个风险变量的组合。除了标准风险变量外，与未聚集的成年人相比，聚集的成年人的总胆固醇、甘油三酯、LDL胆固醇、HDL胆固醇、舒张压和葡萄糖水平也不利（P < 0.001）。除血糖外，儿童期变量显示出不利趋势，成年期标准风险变量数量增加（趋势P，0.01-0.0001）。在儿童期BMI中，成年后出现聚集性的个体比例增加（趋势P
The occurrence of insulin resistance syndrome (syndrome X) is common in the general population. However, information is scant on the childhood predictors of syndrome X. This study examined the relative contribution of childhood adiposity and insulin to the adulthood risk of developing syndrome X in a biracial (black-white) community-based longitudinal cohort (n = 745; baseline age, 8-17 years; mean +/- SD follow-up period, 11.6 +/- 3.4 years). The four criterion risk variables considered were the highest quartile (specific for age, race, sex, and study year) of 1) BMI, 2) fasting insulin, 3) systolic or mean arterial blood pressure, and 4) total cholesterol to HDL cholesterol ratio or triglycerides to HDL cholesterol ratio. Clustering was defined as the combination of all four risk variables. In addition to the criterion risk variables, clustered adults had adverse levels of total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, diastolic blood pressure, and glucose compared with those who did not cluster (P < 0.001). Childhood variables, except glucose, showed adverse trends with increasing number of criterion risk variables present in adulthood (P for trend, 0.01-0.0001). The proportion of individuals who developed clustering as adults increased across childhood BMI (P for trend