fMRI evidence that the neural basis of response inhibition is task-dependent
fMRI evidence that the neural basis of response inhibition is task-dependent
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DOI：
10.1016/s0926-6410(03)00144-7
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发表时间：
2003-07-01
期刊：
影响因子：
--
通讯作者：
Pekar, JJ
中科院分区：
文献类型：
--
作者：
Mostofsky, SH;Schafer, JGB;Pekar, JJ
事件相关功能磁共振成像被用来研究反应抑制所涉及的神经活动取决于反应被抑制的性质的假设。研究人员比较了两种不同的进行/不进行任务--一项工作记忆负荷高，另一项工作记忆负荷低。在工作记忆负荷较低的“简单”进行/不进行任务中，受试者需要按下按钮来响应绿色宇宙飞船，而不是红色宇宙飞船。“数数”进行/不进行任务(高工作记忆负荷)要求受试者对绿色宇宙飞船以及前面有偶数个绿色宇宙飞船的红色宇宙飞船做出反应。在这两个任务中，刺激每隔1.5分钟呈现一次，S的绿色和红色飞船的比例为5：1。使用随机效应模型分析每个任务的fMRI组数据，以确定与GO事件和NO-GO事件(校正后的P值小于或等于0.05)相关的信号变化模式。在这两个任务中，GO反应与左侧初级感觉运动皮质、辅助运动区(SMA)和小脑前部(右侧和左侧)的信号变化有关。对于简单的任务，No-Go事件与SMA前脑区的激活有关；加载工作记忆的“计数”任务在右侧背外侧前额叶皮质引发了额外的No-Go激活。这些发现表明，神经对反应抑制的贡献可能与任务有关；前SMA似乎是抑制不想要的运动所必需的，而背外侧前额叶皮质被招募来完成涉及工作记忆负荷增加的任务。(C)2003爱思唯尔B.V.保留所有权利。
Event-related fMRI was used to investigate the hypothesis that neural activity involved in response inhibition depends upon the nature of the response being inhibited. Two different Go/No-go tasks were compared-one with a high working memory load and one with low. The 'simple' Go/No-go task with low working memory load required subjects to push a button in response to green spaceships but not red spaceships. A 'counting' Go/No-go task (high working memory load) required subjects to respond to green spaceships as well as to those red spaceships preceded by an even number of green spaceships. In both tasks, stimuli were presented every 1.5 s with a 5:1 ratio of green-to-red spaceships. fMRI group data for each task were analyzed using random effects models to determine signal change patterns associated with Go events and No-go events (corrected Pless than or equal to0.05). For both tasks, Go responses were associated with signal change in the left primary sensorimotor cortex, supplementary motor area (SMA) proper, and anterior cerebellum (right>left). For the simple task, No-go events were associated with activation in the pre-SMA; the working memory-loaded 'counting' task elicited additional No-go activation in the right dorsolateral prefrontal cortex. The findings suggest that neural contributions to response inhibition may be task dependent; the pre-SMA appears necessary for inhibition of unwanted movements, while the dorsolateral prefrontal cortex is recruited for tasks involving increased working memory load. (C) 2003 Elsevier B.V. All rights reserved.