Developmental Changes in Autonomic Nervous System Resting and Reactivity Measures in Latino Children from 6 to 60 Months of Age
Developmental Changes in Autonomic Nervous System Resting and Reactivity Measures in Latino Children from 6 to 60 Months of Age
复制标题
DOI：
10.1097/dbp.0b013e3182331fa6
复制
发表时间：
2011-11-01
影响因子：
2.4
通讯作者：
Eskenazi, Brenda
中科院分区：
文献类型：
--
作者：
Alkon, Abbey;Boyce, W. Thomas;Eskenazi, Brenda
目的：本研究描述了一群主要是拉丁裔的低收入儿童在生命的前 5 年中自主神经系统 (ANS) 休息和挑战反应的发育变化和个体稳定性。方法：对 6、12、42 和 60 个月龄 (N = 378) 的全队列代表性样本收集副交感神经系统（呼吸性窦性心律失常 [RSA]）和交感神经系统（射血前期 [PEP]）的 ANS 测量。孩子们参加了一项标准化方案，以在休息和挑战性状态下引发 ANS 反应。创建反应性概况是为了总结每个孩子的 RSA 和 PEP 综合反应性（即与静息状态相比，对挑战的反应变化）。结果：结果显示 6 至 60 个月期间 ANS 指标的发育变化：心率下降、RSA 增加、PEP 增加、交感神经相互激活和副交感神经撤退的经典反应谱的频率增加。相关性显示出在休息和挑战性条件下的中等稳定性，但没有反应性。结论：这些研究结果表明，6 至 60 个月大的低收入拉丁裔儿童表现出 ANS 发育变化，并且在休息和挑战反应方面表现出中等的个体稳定性，但在反应性方面则不然。从 6 个月到 60 个月，具有典型反应特征的儿童的频率发生了显着变化。这是第一个队列研究，显示 ANS 的发育变化以及幼儿在生命的前 5 年内对环境的生物敏感性的增加。 (J Dev Behav Pediatr 32:668-677, 2011)
Objective: This study describes the developmental changes and individual stability in autonomic nervous system (ANS) resting and challenge responses for a cohort of primarily Latino, low-income children during the first 5 years of life. Methods: ANS measures of the parasympathetic nervous system (respiratory sinus arrhythmia [RSA]) and sympathetic nervous system (preejection period [PEP]) were collected on a representative sample of the full cohort at 6, 12, 42, and 60 months of age (N = 378). The children participated in a standardized protocol to elicit ANS responses during resting and challenging states. Reactivity profiles were created to summarize each child's combined RSA and PEP reactivity (i.e., change in response to challenges compared to a resting state). Results: Results showed developmental changes in ANS measures from 6 to 60 months: heart rate decreased, RSA increased, PEP increased, and frequency of classic reactivity profiles of reciprocal sympathetic activation and parasympathetic withdrawal increased. Correlations showed moderate stability for resting and challenging conditions but not reactivity. Conclusions: These findings suggest that low-income Latino children, from 6 to 60 months of age, showed ANS developmental changes and moderate individual stability for resting and challenge responses but not for reactivity. There was a significant shift in the frequency of children with the classic reactivity profile from 6 by 60 months of age. This is the first cohort study to show the developmental changes in ANS and young children's increase in their biologic sensitivity to the environment during the first 5 years of life. (J Dev Behav Pediatr 32:668-677, 2011)