Therapeutic responses to tricyclic antidepressants and related drugs in non-affective disorder patient populations
Therapeutic responses to tricyclic antidepressants and related drugs in non-affective disorder patient populations
复制标题
非情感障碍患者群体对三环类抗抑郁药和相关药物的治疗反应
DOI：
10.1016/0278-5846(85)90174-5
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发表时间：
1985
影响因子：
5.6
通讯作者：
T. Insel
中科院分区：
文献类型：
--
作者：
D. Murphy;L. Siever;T. Insel
Murphy, Dennis L., Larry J. Siever和Thomas R. Insel：非情感性障碍患者对三环类抗抑郁药及相关药物的治疗反应。掠夺。Neuropsychopharmacol。和杂志。精神病学杂志，1985,9(1):3-13。1. 1. 虽然对三环类抗抑郁药物的治疗反应性主要与情感性疾病有关，但过去十年的临床研究表明，非情感性疾病，如恐慌症、强迫症、焦虑症、贪食症、遗尿症、偏头痛和慢性疼痛综合征也可能对三环类药物和其他抗抑郁药物有反应。2. 2. 这种治疗反应性有时可能与继发性抑郁症状的改善有关，但也可能明显发生在没有继发性抑郁的情况下；特别是，至少其中一些疾病的核心症状的改善可能在情绪没有改变的情况下发生。3. 3. 此外，与情感障碍患者相比，许多患有这些障碍的患者表现出心理生物学异常，这些异常显示出许多相似之处，但也有一些差异，尽管经常没有情感症状。4. 4. 虽然亚临床或“隐性”抑郁症的改善仍然是将三环反应性与这一不同诊断实体组中共享的生物学异常联系起来的一种假设，但提出了另一种假设（“均匀障碍”假设），表明三环和其他抗抑郁反应患者可能具有常见心理生物学异常的核心障碍，但有多种临床和诊断表现。5. 5. 另一种假说（“散弹枪假说”）认为，三环类药物的多种作用（如肾上腺素能受体vs毒蕈碱受体vs血清素系统改变）对这些区域中某一特定或主要问题的患者的治疗结果可能各有不同的重要作用。
Abstract Murphy, Dennis L., Larry J. Siever and Thomas R. Insel: Therapeutic responses to tricyclic antidepressants and related drugs in non-affective disorder patient populations. Prog. Neuropsychopharmacol. and Biol. Psychiat. 1985, 9 (1): 3–13. 1. 1. Although therapeutic responsiveness to tricyclic antidepressants has been primarily associated with the affective disorders, clinical investigations in the last decade have suggested that non-affective disorders such as panic disorder, obsessive-compulsive disorder, anxiety disorder, bulimia, eneuresis, migraine, and the chronic pain syndrome may also respond to tricyclics and other antidepressants. 2. 2. This therapeutic responsiveness may sometimes be related to improvement in secondary depressive symptoms, but may also clearly occur in the absence of secondary depression; in particular, improvement in the core symptoms of at least some of these disorders may occur without a change in mood. 3. 3. Furthermore, many patients with these disorders display psychobiologic abnormalities that show many similarities, but also some differences, compared to those observed in patients with affective disorders, despite the frequent absence of affective symptoms. 4. 4. While an improvement in subclinical or “masked” depression remains one hypothesis linking tricyclic responsiveness and shared biological abnormalities in this diverse group of diagnostic entities, an alternative hypothesis (the “ven disorder” hypothesis) is presented, suggesting the possibility that tricyclic and other antidepressant-responding patients have a core disorder with common psychobiologic abnormalities but multiple clinical and diagnostic presentations. 5. 5. An alternative hypothesis (the “shotgun” hypothesis) suggests that the multiple actions of tricyclics (eg on adrenergic receptors vs. muscarinic receptors vs. serotonin system changes) may each be differentially important in the therapeutic outcome in patients with specific or predominant problems in one or another of these areas.
影响因子：
--
作者：
Leckman,JF;Weissman,MM;Merikangas,KR;Pauls,DL;Prusoff,BA
通讯作者：
Prusoff,BA
抗抑郁药的抗毒蕈碱和其他受体阻断特性。
DOI：
--
发表时间：
1983
期刊：
Mayo Clinic proceedings. Mayo Clinic
影响因子：
--
作者：
Richelson,E
通讯作者：
Richelson,E