Accurate genetic profiling of anthropometric traits using a big data approach
Accurate genetic profiling of anthropometric traits using a big data approach
复制标题
使用大数据方法对人体测量特征进行准确的遗传分析
DOI：
10.1101/033134
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Canela-Xandri O
中科院分区：
文献类型：
--
作者：
Canela-Xandri O
全基因组关联研究（GWAS）承诺通过预测疾病风险为个体定制疾病管理，将其发现转化为临床有益的患者管理改进1，2。然而，到目前为止，将GWAS的遗传发现转化为具有临床实用性并可告知临床实践的预测工具的能力令人鼓舞但有限。在这里，我们建议使用一种更强大的统计方法，能够预测多种医学相关的表型，而无需为每个表型开发基因检测的相关成本。作为原理的证明，我们使用了一个由319，038个SNPs组成的通用面板，在114，264名无关的英国白人中训练预测模型，用于身高和四个肥胖相关特征（体重指数，基础代谢率，体脂百分比和腰臀比）。我们得到的预测精度范围在46%和75%之间的最大可实现的解释遗传成分。这比通过大型合作开发的预测器解释的表型方差提高了75%，其中使用了两倍多的训练样本。在白色非英国人的跨人群预测是类似的白人英国人，而在亚洲和黑人个人的信息，但不太准确。大约50万名英国生物库参与者的基因分型将产生最大值的66%至83%之间的预测。我们预计，我们的模型和一组通用的遗传标记（可用于多种性状和疾病）将成为为个体量身定制疾病管理的起点。最终，我们将能够利用全基因组序列和环境风险因素来实现基因组医学的全部潜力。
Genome-wide association studies (GWAS) promised to translate their findings into clinically beneficial improvements of patient management by tailoring disease management to the individual through the prediction of disease risk1,2. However, the ability to translate genetic findings from GWAS into predictive tools that are of clinical utility and which may inform clinical practice has, so far, been encouraging but limited,. Here we propose to use a more powerful statistical approach that enables the prediction of multiple medically relevant phenotypes without the costs associated with developing a genetic test for each of them. As a proof of principle, we used a common panel of 319,038 SNPs to train the prediction models in 114,264 unrelated White-British for height and four obesity related traits (body mass index, basal metabolic rate, body fat percentage, and waist-to-hip ratio). We obtained prediction accuracies that ranged between 46% and 75% of the maximum achievable given their explained heritable component. This represents an improvement of up to 75% over the phenotypic variance explained by the predictors developed through large collaborations, which used more than twice as many training samples. Across-population predictions in White nonBritish individuals were similar to those of White-British whilst those in Asian and Black individuals were informative but less accurate. The genotyping of circa 500,000 UK Biobank participants will yield predictions ranging between 66% and 83% of the maximum. We anticipate that our models and a common panel of genetic markers, which can be used across multiple traits and diseases, will be the starting point to tailor disease management to the individual. Ultimately, we will be able to capitalise on whole-genome sequence and environmental risk factors to realise the full potential of genomic medicine.
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影响因子：
30.8
作者：
Biesecker, BB;Marteau, TM
通讯作者：
Marteau, TM
影响因子：
64.8
作者：
Locke, Adam E.;Kahali, Bratati;Berndt, Sonja I.;Justice, Anne E.;Pers, Tune H.;Day, Felix R.;Powell, Corey;Vedantam, Sailaja;Buchkovich, Martin L.;Yang, Jian;Croteau-Chonka, Damien C.;Esko, Tonu;Fall, Tove;Ferreira, Teresa;Gustafsson, Stefan;Kutalik, Zoltan;Luan, Jian'an;Maegi, Reedik;Randall, Joshua C.;Winkler, Thomas W.;Wood, Andrew R.;Workalemahu, Tsegaselassie;Faul, Jessica D.;Smith, Jennifer A.;Zhao, Jing Hua;Zhao, Wei;Chen, Jin;Fehrmann, Rudolf;Hedman, Asa K.;Karjalainen, Juha;Schmidt, Ellen M.;Absher, Devin;Amin, Najaf;Anderson, Denise;Beekman, Marian;Bolton, Jennifer L.;Bragg-Gresham, L.;Buyske, Steven;Demirkan, Ayse;Deng, Guohong;Ehret, Georg B.;Feenstra, Bjarke;Feitosa, Mary F.;Fischer, Krista;Goel, Anuj;Gong, Jian;Jackson, Anne U.;Kanoni, Stavroula;Kleber, Marcus E.;Kristiansson, Kati;Lim, Unhee;Lotay, Vaneet;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Medland, Sarah E.;Nalls, Michael A.;Palmer, Cameron D.;Pasko, Dorota;Pechlivanis, Sonali;Peters, Marjolein J.;Prokopenko, Inga;Shungin, Dmitry;Stancakova, Alena;Strawbridge, Rona J.;Sung, Yun Ju;Tanaka, Toshiko;Teumer, Alexander;Trompet, Stella;van der Laan, Sander W.;van Settee, Jessica;Van Vliet-Ostaptchouk, Jana V.;Wang, Zhaoming;Yengo, Loic;Zhang, Weihua;Isaacs, Aaron;Albrecht, Eva;Arnlov, Johan;Arscott, Gillian M.;Attwood, Antony P.;Bandinelli, Stefania;Barrett, Amy;Bas, Isabelita N.;Bellis, Claire;Bennett, Amanda J.;Berne, Christian;Blagieva, Roza;Blueher, Matthias;Bohringer, Stefan;Bonnycastle, Lori L.;Boettcher, Yvonne;Boyd, Heather A.;Bruinenberg, Marcel;Caspersen, Ida H.;Chen, Yii-Der Ida;Clarke, Robert;Daw, E. Warwick;de Craen, Anton J. M.;Delgado, Graciela;Dimitriou, Maria;Doney, Alex S. F.;Eklund, Niina;Estrada, Karol;Eury, Elodie;Folkersen, Lasse;Fraser, Ross M.;Garcia, Melissa E.;Geller, Frank;Giedraitis, Vilmantas;Gigante, Bruna;Go, Alan S.;Golay, Alain;Goodall, Alison H.;Gordon, Scott D.;Gorski, Mathias;Grabe, Hans-Joergen;Grallert, Harald;Grammer, Tanja B.;Graessler, Jurgen;Gronberg, Henrik;Groves, Christopher J.;Gusto, Gaeelle;Haessler, Jeffrey;Hall, Per;Haller, Toomas;Hallmans, Goran;Hartman, Catharina A.;Hassinen, Maija;Hayward, Caroline;Heard-Costa, Nancy L.;Helmer, Qinta;Hengstenberg, Christian;Holmen, Oddgeir;Hottenga, Jouke-Jan;James, Alan L.;Jeff, Janina M.;Johansson, Asa;Jolley, Jennifer;Juliusdottir, Thorhildur;Kinnunen, Leena;Koenig, Wolfgang;Koskenvuo, Markku;Kratzer, Wolfgang;Laitinen, Jaana;Lamina, Claudia;Leander, Karin;Lee, Nanette R.;Lichtner, Peter;Lind, Lars;Lindstrom, Jaana;Lo, Ken Sin;Lobbens, Stephane;Lorbeer, Roberto;Lu, Yingchang;Mach, Francois;Magnusson, Patrik K. E.;Mahajan, Anubha;McArdle, Wendy L.;McLachlan, Stela;Menni, Cristina;Merger, Sigrun;Mihailov, Evelin;Milani, Lili;Moayyeri, Alireza;Monda, Keri L.;Morken, Mario A.;Mulas, Antonella;Mueller, Gabriele;Mueller-Nurasyid, Martina;Musk, Arthur W.;Nagaraja, Ramaiah;Noethen, Markus M.;Nolte, Ilja M.;Pilz, Stefan;Rayner, Nigel W.;Renstrom, Frida;Rettig, Rainer;Ried, Janina S.;Ripke, Stephan;Robertson, Neil R.;Rose, Lynda M.;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Schumacher, Fredrick R.;Scott, William R.;Seufferlein, Thomas;Shi, Jianxin;Smith, Albert Vernon;Smolonska, Joanna;Stanton, Alice V.;Steinthorsdottir, Valgerdur;Stirrups, Kathleen;Stringham, Heather M.;Sundstrom, Johan;Swertz, Morris A.;Swift, Amy J.;Syvanen, Ann-Christine;Tan, Sian-Tsung;Tayo, Bamidele O.;Thorand, Barbara;Thorleifsson, Gudmar;Tyrer, Jonathan P.;Uh, Hae-Won;Vandenput, Liesbeth;Verhulst, Frank C.;Vermeulen, Sita H.;Verweij, Niek;Vonk, Judith M.;Waite, Lindsay L.;Warren, Helen R.;Waterworth, Dawn;Weedon, Michael N.;Wilkens, Lynne R.;Willenborg, Christina;Wilsgaard, Tom;Wojczynski, Mary K.;Wong, Andrew;Wrightl, Alan F.;Zhang, Qunyuan;Brennan, Eoin P.;Choi, Murim;Dastani, Zari;Drong, Alexander W.;Eriksson, Per;Franco-Cereceda, Anders;Gadin, Jesper R.;Gharavi, Ali G.;Goddard, Michael E.;Handsaker, Robert E.;Huang, Jinyan;Karpe, Fredrik;Kathiresan, Sekar;Keildson, Sarah;Kiryluk, Krzysztof;Kubo, Michiaki;Lee, Jong-Young;Liang, Liming;Lifton, Richard P.;Ma, Baoshan;McCarroll, Steven A.;McKnight, Amy J.;Min, Josine L.;Moffatt, Miriam F.;Montgomery, Grant W.;Murabito, Joanne M.;Nicholson, George;Nyholt, Dale R.;Okada, Yukinori;Perry, John R. B.;Dorajoo, Rajkumar;Reinmaa, Eva;Salem, Rany M.;Sandholm, Niina;Scott, Robert A.;Stolk, Lisette;Takahashi, Atsushi;Tanaka, Toshihiro;van 't Hooft, Ferdinand M.;Vinkhuyzen, Anna A. E.;Westra, Harm-Jan;Zheng, Wei;Zondervan, Krina T.;Heath, Andrew C.;Arveiler, Dominique;Bakker, Stephan J. L.;Beilby, John;Bergman, Richard N.;Blangero, John;Bovet, Pascal;Campbell, Harry;Caulfield, Mark J.;Cesana, Giancarlo;Chakravarti, Aravinda;Chasman, Daniel I.;Chines, Peter S.;Collins, Francis S.;Crawford, Dana C.;Cupples, L. Adrienne;Cusi, Daniele;Danesh, John;de Faire, Ulf;den Ruijter, Hester M.;Dominiczak, Anna F.;Erbel, Raimund;Erdmann, Jeanette;Eriksson, Johan G.;Farrall, Martin;Felix, Stephan B.;Ferrannini, Ele;Ferrieres, Jean;Ford, Ian;Forouhi, Nita G.;Forrester, Terrence;Franco, Oscar H.;Gansevoort, Ron T.;Gejman, Pablo V.;Gieger, Christian;Gottesman, Omri;Gudnason, Vilmundur;Gyllensten, Ulf;Hall, Alistair S.;Harris, Tamara B.;Hattersley, Andrew T.;Hicks, Andrew A.;Hindorff, Lucia A.;Hingorani, Aroon D.;Hofman, Albert;Homuth, Georg;Hovingh, G. Kees;Humphries, Steve E.;Hunt, Steven C.;Hypponen, Elina;Illig, Thomas;Jacobs, Kevin B.;Jarvelin, Marjo-Riitta;Joeckel, Karl-Heinz;Johansen, Berit;Jousilahti, Pekka;Jukema, J. Wouter;Jula, Antti M.;Kaprio, Jaakko;Kastelein, John J. P.;Keinanen-Kiukaanniemi, Sirkka M.;Kiemeney, Lambertus A.;Knekt, Paul;Kooner, Jaspal S.;Kooperberg, Charles;Kovacs, Peter;Kraja, Aldi T.;Kumari, Meena;Kuusisto, Johanna;Lakka, Timo A.;Langenberg, Claudia;Le Marchand, Laic;Lehtimaki, Terho;Lyssenko, Valeriya;Mannisto, Satu;Marette, Andre;Matise, Tara C.;McKenzie, Colin A.;McKnight, Barbara;Moll, Frans L.;Morris, Andrew D.;Morris, Andrew P.;Murray, Jeffrey C.;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J.;Ong, Ken K.;Madden, Pamela A. F.;Pasterkamp, Gerard;Peden, John F.;Peters, Annette;Postma, Dirkje S.;Pramstaller, Peter P.;Price, Jackie F.;Qi, Lu;Raitakari, Olli T.;Rankinen, Tuomo;Rao, D. C.;Rice, Treva K.;Ridker, Paul M.;Rioux, John D.;Ritchie, Marylyn D.;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J.;Saramines, Jouko;Sarzynski, Mark A.;Schunkert, Heribert;Schwarz, Peter E. H.;Sever, Peter;Shuldiner, Alan R.;Sinisalo, Juha;Stolk, Ronald P.;Strauch, Konstantin;Toenjes, Anke;Tregouet, David-Alexandre;Tremblay, Angelo;Tremoli, Elena;Virtamo, Jarmo;Vohl, Marie-Claude;Voelker, Uwe;Waeber, Gerard;Willemsen, Gonneke;Witteman, Jacqueline C.;Zillikens, M. Carola;Adair, Linda S.;Amouyel, Philippe;Asselbergs, Folkert W.;Assimes, Themistocles L.;Bochud, Murielle;Boehm, Bernhard O.;Boerwinkle, Eric;Bornstein, Stefan R.;Bottinger, Erwin P.;Bouchard, Claude;Cauchi, Stephane;Chambers, John C.;Chanock, Stephen J.;Cooper, Richard S.;de Bakker, Paul I. W.;Dedoussis, George;Ferrucci, Luigi;Franks, Paul W.;Froguel, Philippe;Groop, Leif C.;Haiman, Christopher A.;Hamsten, Anders;Hui, Jennie;Hunter, David J.;Hveem, Kristian;Kaplan, Robert C.;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Martin, Nicholas G.;Maerz, Winfried;Melbve, Mads;Metspalu, Andres;Moebus, Susanne;Munroe, Patricia B.;Njolstad, Inger;Oostra, Ben A.;Palmer, Colin N. A.;Pedersen, Nancy L.;Perola, Markus;Perusse, Louis;Peters, Ulrike;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Rivadeneira, Fernando;Saaristo, Timo E.;Saleheen, Danish;Sattar, Naveed;Schadt, Eric E.;Schlessinger, David;Slagboom, P. Eline;Snieder, Harold;Spector, Tim D.;Thorsteinsdottir, Unnu R.;Stumvoll, Michael;Tuomilehto, Jaakko;Uitterlinden, Andre G.;Uusitupa, Matti;van der Harst, Pim;Walker, Mark;Wallaschofski, Henri;Wareham, Nicholas J.;Watkins, Hugh;Weir, David R.;Wichmann, H-Erich;Wilson, James F.;Zanen, Pieter;Borecki, Ingrid B.;Deloukas, Panos;Fox, Caroline S.;Heid, Iris M.;O'Connell, Jeffrey R.;Strachan, David P.;Stefansson, Kari;van Duijri, Cornelia M.;Abecasis, Goncalo R.;Franke, Lude;Frayling, Timothy M.;McCarthy, Mark I.;Visscher, Peter M.;Scherag, Andre;Willer, Cristen J.;Boehnke, Michael;Mohlke, Karen L.;Lindgren, Cecilia M.;Beckmann, Jacques S.;Barroso, Ines;North, Kari E.;Ingelsson, Erik;Hirschhorn, Joel N.;Loos, Ruth J. F.;Speliotes, Elizabeth K.
通讯作者：
Speliotes, Elizabeth K.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
30.8
作者：
Wood, Andrew R.;Esko, Tonu;Yang, Jian;Vedantam, Sailaja;Pers, Tune H.;Gustafsson, Stefan;Chun, Audrey Y.;Estrada, Karol;Luan, Jian'an;Kutalik, Zoltan;Amin, Najaf;Buchkovich, Martin L.;Croteau-Chonka, Damien C.;Day, Felix R.;Duan, Yanan;Fall, Tove;Fehrmann, Rudolf;Ferreira, Teresa;Jackson, Anne U.;Karjalainen, Juha;Lo, Ken Sin;Locke, Adam E.;Maegi, Reedik;Mihailov, Evelin;Porcu, Eleonora;Randall, Joshua C.;Scherag, Andre;Vinkhuyzen, Anna A. E.;Westra, Harm-Jan;Winkler, Thomas W.;Workalemahu, Tsegaselassie;Zhao, Jing Hua;Absher, Devin;Albrecht, Eva;Anderson, Denise;Baron, Jeffrey;Beekman, Marian;Demirkan, Ayse;Ehret, Georg B.;Feenstra, Bjarke;Feitosa, Mary F.;Fischer, Krista;Fraser, Ross M.;Goel, Anuj;Gong, Jian;Justice, Anne E.;Kanoni, Stavroula;Kleber, Marcus E.;Kristiansson, Kati;Lim, Unhee;Lotay, Vaneet;Lui, Julian C.;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Nalls, Michael A.;Nyholt, Dale R.;Palmer, Cameron D.;Pasko, Dorota;Pechlivanis, Sonali;Prokopenko, Inga;Ried, Janina S.;Ripke, Stephan;Shungin, Dmitry;Stancakova, Alena;Strawbridge, Rona J.;Sung, Yun Ju;Tanaka, Toshiko;Teumer, Alexander;Trompet, Stella;van der Laan, Sander W.;van Setten, Jessica;Van Vliet-Ostaptchouk, Jana V.;Wang, Zhaoming;Yengo, Loic;Zhang, Weihua;Afzal, Uzma;Arnloev, Johan;Arscott, Gillian M.;Bandinelli, Stefania;Barrett, Amy;Bellis, Claire;Bennett, Amanda J.;Berne, Christian;Blueher, Matthias;Bolton, Jennifer L.;Boettcher, Yvonne;Boyd, Heather A.;Bruinenberg, Marcel;Buckley, Brendan M.;Buyske, Steven;Caspersen, Ida H.;Chines, Peter S.;Clarke, Robert;Claudi-Boehm, Simone;Cooper, Matthew;Daw, E. Warwick;De Jong, Pim A.;Deelen, Joris;Delgado, Graciela;Denny, Josh C.;Dhonukshe-Rutten, Rosalie;Dimitriou, Maria;Doney, Alex S. F.;Doerr, Marcus;Eklund, Niina;Eury, Elodie;Folkersen, Lasse;Garcia, Melissa E.;Geller, Frank;Giedraitis, Vilmantas;Go, Alan S.;Grallert, Harald;Grammer, Tanja B.;Graessler, Juergen;Groenberg, Henrik;de Groot, Lisette C. P. G. M.;Groves, Christopher J.;Haessler, Jeffrey;Hall, Per;Haller, Toomas;Hallmans, Goran;Hannemann, Anke;Hartman, Catharina A.;Hassinen, Maija;Hayward, Caroline;Heard-Costa, Nancy L.;Helmer, Quinta;Hemani, Gibran;Henders, Anjali K.;Hillege, Hans L.;Hlatky, Mark A.;Hoffmann, Wolfgang;Hoffmann, Per;Holmen, Oddgeir;Houwing-Duistermaat, Jeanine J.;Illig, Thomas;Isaacs, Aaron;James, Alan L.;Jeff, Janina;Johansen, Bent;Johansson, Asa;Jolley, Jennifer;Juliusdottir, Thorhildur;Junttila, Juhani;Kho, Abel N.;Kinnunen, Leena;Klopp, Norman;Kocher, Thomas;Kratzer, Wolfgang;Lichtner, Peter;Lind, Lars;Lindstroem, Jaana;Lobbens, Stephane;Lorentzon, Mattias;Lu, Yingchang;Lyssenko, Valeriya;Magnusson, Patrik K. E.;Mahajan, Anubha;Maillard, Marc;McArdle, Wendy L.;McKenzie, Colin A.;McLachlan, Stela;McLaren, Paul J.;Menni, Cristina;Merger, Sigrun;Milani, Lili;Moayyeri, Alireza;Monda, Keri L.;Morken, Mario A.;Mueller, Gabriele;Mueller-Nurasyid, Martina;Musk, Arthur W.;Narisu, Narisu;Nauck, Matthias;Nolte, Ilja M.;Noethen, Markus M.;Oozageer, Laticia;Pilz, Stefan;Rayner, Nigel W.;Renstrom, Frida;Robertson, Neil R.;Rose, Lynda M.;Roussel, Ronan;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Schumacher, Fredrick R.;Schunkert, Heribert;Scott, Robert A.;Sehmi, Joban;Seufferlein, Thomas;Shin, Jianxin;Silventoinen, Karri;Smit, Johannes H.;Smith, Albert Vernon;Smolonska, Joanna;Stanton, Alice V.;Stirrups, Kathleen;Stott, David J.;Stringham, Heather M.;Sundstrom, Johan;Swertz, Morris A.;Syvanen, Ann-Christine;Tayo, Bamidele O.;Thorleifsson, Gudmar;Tyrer, Jonathan P.;van Dijk, Suzanne;van Schoor, Natasja M.;van der Velde, Nathalie;van Heemst, Diana;van Oort, Floor V. A.;Vermeulen, Sita H.;Verweij, Niek;Vonk, Judith M.;Waite, Lindsay L.;Waldenberger, Melanie;Wennauer, Roman;Wilkens, Lynne R.;Willenborg, Christina;Wilsgaard, Tom;Wojczynski, Mary K.;Wong, Andrew;Wright, Alan F.;Zhang, Qunyuan;Arveiler, Dominique;Bakker, Stephan J. L.;Beilby, John;Bergman, Richard N.;Bergmann, Sven;Biffar, Reiner;Blangero, John;Boomsma, Dorret I.;Bornstein, Stefan R.;Bovet, Pascal;Brambilla, Paolo;Brown, Morris J.;Campbell, Harry;Caulfield, Mark J.;Chakravarti, Aravinda;Collins, Rory;Collins, Francis S.;Crawford, Dana C.;Cupples, L. Adrienne;Danesh, John;de Faire, Ulf;den Ruijter, Hester M.;Erbel, Raimund;Erdmann, Jeanette;Eriksson, Johan G.;Farrall, Martin;Ferrannini, Ele;Ferrieres, Jean;Ford, Ian;Forouhi, Nita G.;Forrester, Terrence;Gansevoort, Ron T.;Gejman, Pablo V.;Gieger, Christian;Golay, Alain;Gottesman, Omri;Gudnason, Vilmundur;Gyllensten, Ulf;Haas, David W.;Hall, Alistair S.;Harris, Tamara B.;Hattersley, Andrew T.;Heath, Andrew C.;Hengstenberg, Christian;Hicks, Andrew A.;Hindorff, Lucia A.;Hingorani, Aroon D.;Hofman, Albert;Hovingh, G. Kees;Humphries, Steve E.;Hunt, Steven C.;Hypponen, Elina;Jacobs, Kevin B.;Jarvelin, Marjo-Riitta;Jousilahti, Pekka;Jula, Antti M.;Kaprio, Jaakko;Kastelein, John J. P.;Kayser, Manfred;Kee, Frank;Keinanen-Kiukaanniemi, Sirkka M.;Kiemeney, Lambertus A.;Kooner, Jaspal S.;Kooperberg, Charles;Koskinen, Seppo;Kovacs, Peter;Kraja, Aldi T.;Kumari, Meena;Kuusisto, Johanna;Lakka, Timo A.;Langenberg, Claudia;Le Marchand, Loic;Lehtimaki, Terho;Lupoli, Sara;Madden, Pamela A. F.;Mannisto, Satu;Manunta, Paolo;Marette, Andre;Matise, Tara C.;McKnight, Barbara;Meitinger, Thomas;Moll, Frans L.;Montgomery, Grant W.;Morris, Andrew D.;Morris, Andrew P.;Murray, Jeffrey C.;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J.;Ong, Ken K.;Ouwehand, Willem H.;Pasterkamp, Gerard;Peters, Annette;Pramstaller, Peter P.;Price, Jackie F.;Qi, Lu;Raitakari, Olli T.;Rankinen, Tuomo;Rao, D. C.;Rice, Treva K.;Ritchie, Marylyn;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J.;Saramies, Jouko;Sarzynski, Mark A.;Schwarz, Peter E. H.;Sebert, Sylvain;Sever, Peter;Shuldiner, Alan R.;Sinisalo, Juha;Steinthorsdottir, Valgerdur;Stolk, Ronald P.;Tardif, Jean-Claude;Toenjes, Anke;Tremblay, Angelo;Tremoli, Elena;Virtamo, Jarmo;Vohl, Marie-Claude;Amouyel, Philippe;Asselbergs, Folkert W.;Assimes, Themistocles L.;Bochud, Murielle;Boehm, Bernhard O.;Boerwinkle, Eric;Bottinger, Erwin P.;Bouchard, Claude;Cauchi, Stephane;Chambers, John C.;Chanock, Stephen J.;Cooper, Richard S.;de Bakker, Paul I. W.;Dedoussis, George;Ferrucci, Luigi;Franks, Paul W.;Froguel, Philippe;Groop, Leif C.;Haiman, Christopher A.;Hamsten, Anders;Hayes, M. Geoffrey;Hui, Jennie;Hunter, David J.;Hveem, Kristian;Jukema, J. Wouter;Kaplan, Robert C.;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Martin, Nicholas G.;Maerz, Winfried;Melbye, Mads;Moebus, Susanne;Munroe, Patricia B.;Njolstad, Inger;Oostra, Ben A.;Palmer, Colin N. A.;Pedersen, Nancy L.;Perola, Markus;Perusse, Louis;Peters, Ulrike;Powell, Joseph E.;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Reinmaa, Eva;Ridker, Paul M.;Rivadeneira, Fernando;Rotter, Jerome I.;Saaristo, Timo E.;Saleheen, Danish;Schlessinger, David;Slagboom, P. Eline;Snieder, Harold;Spector, Tim D.;Strauch, Konstantin;Stumvoll, Michael;Tuomilehto, Jaakko;Uusitupa, Matti;van der Harst, Pim;Voelzke, Henry;Walker, Mark;Wareham, Nicholas J.;Watkins, Hugh;Wichmann, H-Erich;Wilson, James F.;Zanen, Pieter;Deloukas, Panos;Heid, Iris M.;Lindgren, Cecilia M.;Mohlke, Karen L.;Speliotes, Elizabeth K.;Thorsteinsdottir, Unnur;Barroso, Ines;Fox, Caroline S.;North, Kari E.;Strachan, David P.;Beckmann, Jacques S.;Berndt, Sonja I.;Boehnke, Michael;Borecki, Ingrid B.;McCarthy, Mark I.;Metspalu, Andres;Stefansson, Kari;Uitterlinden, Andre G.;van Duijn, Cornelia M.;Franke, Lude;Willer, Cristen J.;Price, Alkes L.;Lettre, Guillaume;Loos, Ruth J. F.;Weedon, Michael N.;Ingelsson, Erik;O'Connell, Jeffrey R.;Abecasis, Goncalo R.;Chasman, Daniel I.;Goddard, Michael E.;Visscher, Peter M.;Hirschhorn, Joel N.;Frayling, Timothy M.
通讯作者：
Frayling, Timothy M.
影响因子：
9.8
作者：
Purcell, Shaun;Neale, Benjamin;Sham, Pak C.
通讯作者：
Sham, Pak C.