Morphometric analysis of the lung in bronchopulmonary dysplasia.
Morphometric analysis of the lung in bronchopulmonary dysplasia.
复制标题
支气管肺发育不良的肺形态测量分析。
DOI：
10.1164/ajrccm/143.2.391
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Dahms,BB
中科院分区：
文献类型：
--
作者：
Margraf,LR;TomashefskiJr,JF;Bruce,MC;Dahms,BB
BPD 的病理特征已被描述，但很少有形态测量研究将 BPD 婴儿的肺部与没有新生儿肺损伤的婴儿的肺部进行比较 (5-9)。据报道，患有或不患有透明膜疾病的依赖呼吸机的早产儿的肺部肺泡总数减少 (10)。在另一项研究中，一名 34 个月大的患有长期 BPD 且已治愈的儿童的肺泡总数和内表面积显着减少 (8)。该患者的小气道的大小和密度与分别在 26、34 和 41 个月大时未患肺病而死亡的三名儿童的小气道相似。 在这项尸检研究中，我们定量检查了 8 名患有修复性慢性 BPD 的儿童和 6 名没有慢性肺病的儿童的气道和肺实质。我们的研究结果表明，BPD患者的肺部肺泡数量和内表面积大大减少，肺泡直径变大，弹性蛋白纤维的分布和结构异常。我们还观察到大气道和小气道的重塑，以及中央支气管重塑的区域差异。我们的结果表明
The pathologic features of BPD have been delineated, but there are few morphometric studies in which the lungs of infants with BPD have been compared with those in infants without neonatal lung injury (5-9). Decreased total alveolar number has been reported in the lungs of ventilator-dependent, premature infants with or without hyaline membrane disease (10). In a separate study, a marked reduction in total alveolar number and internal surface area was reported in a 34-month-old child with long-standing, healed BPD (8). In that patient the small airways were similar in size and density to those of three children who died without lung disease at 26, 34, and 41months of age, respectively.In this autopsy study wequantitatively examined the airwaysand pulmonary parenchyma of eight children with reparative and chronic BPD and six children without chronic lung disease. The results of our study indicate that the lungs of patients with BPD havegreatly decreased alveolar number and internal surface area, large alveolar diameters, and an abnormal distribution and structure of elastin fibers. Wealso observed remodeling of the large and small airways, with regional variability of remodeling in the central bronchi. Our results indicate that