Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort.
Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort.
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DOI：
10.1002/acr.23712
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发表时间：
2019-07
影响因子：
4.7
通讯作者：
Fritzler MJ
中科院分区：
文献类型：
--
作者：
Choi MY;Clarke AE;St Pierre Y;Hanly JG;Urowitz MB;Romero-Diaz J;Gordon C;Bae SC;Bernatsky S;Wallace DJ;Merrill JT;Isenberg DA;Rahman A;Ginzler EM;Petri M;Bruce IN;Dooley MA;Fortin PR;Gladman DD;Sanchez-Guerrero J;Steinsson K;Ramsey-Goldman R;Khamashta MA;Aranow C;Alarcón GS;Manzi S;Nived O;Zoma AA;van Vollenhoven RF;Ramos-Casals M;Ruiz-Irastorza G;Lim SS;Kalunian KC;Inanc M;Kamen DL;Peschken CA;Jacobsen S;Askanase A;Stoll T;Buyon J;Mahler M;Fritzler MJ
抗核抗体 (ANA) 的范围正在发生变化，包括核染色以及细胞质和有丝分裂细胞模式 (CMP)，因此抗细胞抗体的术语正在发生变化。本研究利用系统性狼疮国际合作诊所初始队列研究了间接免疫荧光 (IIF) 抗细胞抗体染色的流行情况。使用基线血清通过 IIF 在 HEp-2000 基质上检测抗细胞抗体。检查了三个血清学子集：ANA 阳性（存在核或混合核/CMP 染色）、抗细胞抗体阴性（不存在任何细胞内染色）和分离的 CMP 染色。通过多变量分析评估抗细胞抗体阴性与 ANA 或孤立 CMP 阳性的几率。总共纳入了 1,137 名患者； 1,049 例 (92.3%) 为 ANA 阳性，71 例 (6.2%) 为抗细胞抗体阴性，17 例 (1.5%) 为孤立性 CMP。孤立的 CMP 阳性组在临床、人口统计学或血清学特征上与 ANA 阳性或抗细胞抗体阴性组没有差异。年龄较大（比值比 [OR] 1.02 [95% 置信区间 (95% CI) 1.00, 1.04]）、白种人/族裔（OR 3.53 [95% CI 1.77, 7.03]）或在入组时或之前接受高剂量糖皮质激素的患者（OR 2.39 [95% CI 1.39， 4.12]）更有可能是抗细胞抗体阴性。服用免疫抑制剂（OR 0.35 [95% CI 0.19, 0.64]）或抗SSA/Ro 60（OR 0.41 [95% CI 0.23, 0.74]）或抗U1 RNP（OR 0.43 [95% CI 0.20, 0.93]）的患者抗细胞抗体阴性的可能性较小。在新诊断的系统性红斑狼疮中，6.2%的患者抗细胞抗体阴性，1.5%的患者有孤立性CMP。抗细胞抗体阴性系统性红斑狼疮的患病率可能会下降，因为新兴的命名指南建议非核模式也应报告为阳性 ANA。
The spectrum of antinuclear antibodies (ANAs) is changing to include both nuclear staining as well as cytoplasmic and mitotic cell patterns (CMPs) and accordingly a change is occurring in terminology to anticellular antibodies. This study examined the prevalence of indirect immunofluorescence (IIF) anticellular antibody staining using the Systemic Lupus International Collaborating Clinics inception cohort. Anticellular antibodies were detected by IIF on HEp-2000 substrate using the baseline serum. Three serologic subsets were examined: ANA positive (presence of either nuclear or mixed nuclear/CMP staining), anticellular antibody negative (absence of any intracellular staining), and isolated CMP staining. The odds of being anticellular antibody negative versus ANA or isolated CMP positive was assessed by multivariable analysis. A total of 1,137 patients were included; 1,049 (92.3%) were ANA positive, 71 (6.2%) were anticellular antibody negative, and 17 (1.5%) had an isolated CMP. The isolated CMP–positive group did not differ from the ANA-positive or anticellular antibody–negative groups in clinical, demographic, or serologic features. Patients who were older (odds ratio [OR] 1.02 [95% confidence interval (95% CI) 1.00, 1.04]), of white race/ethnicity (OR 3.53 [95% CI 1.77, 7.03]), or receiving high-dose glucocorticoids at or prior to enrollment (OR 2.39 [95% CI 1.39, 4.12]) were more likely to be anticellular antibody negative. Patients on immunosuppressants (OR 0.35 [95% CI 0.19, 0.64]) or with anti-SSA/Ro 60 (OR 0.41 [95% CI 0.23, 0.74]) or anti–U1 RNP (OR 0.43 [95% CI 0.20, 0.93]) were less likely to be anticellular antibody negative. In newly diagnosed systemic lupus erythematosus, 6.2% of patients were anticellular antibody negative, and 1.5% had an isolated CMP. The prevalence of anticellular antibody–negative systemic lupus erythematosus will likely decrease as emerging nomenclature guidelines recommend that non-nuclear patterns should also be reported as a positive ANA.
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DOI：
10.1007/s13317-016-0075-0
发表时间：
2016-12
期刊：
Auto- immunity highlights
影响因子：
--
作者：
Damoiseaux J;von Mühlen CA;Garcia-De La Torre I;Carballo OG;de Melo Cruvinel W;Francescantonio PL;Fritzler MJ;Herold M;Mimori T;Satoh M;Andrade LE;Chan EK;Conrad K
通讯作者：
Conrad K
影响因子：
2.6
作者：
Isenberg, D. A.;Ramsey-Goldman, R.;Hanly, J. G.
通讯作者：
Hanly, J. G.
影响因子：
2.1
作者：
Compagno, M.;Jacobsen, S.;Bengtsson, A. A.
通讯作者：
Bengtsson, A. A.
影响因子：
--
作者：
Hanly, J. G.;Urowitz, M. B.;Merrill, J. T.
通讯作者：
Merrill, J. T.
影响因子：
--
作者：
Mahler, M;Kessenbrock, K;Fritzler, MJ
通讯作者：
Fritzler, MJ