A new program to compute and evaluate continuously monitored stopping boundaries for clinical trials
A new program to compute and evaluate continuously monitored stopping boundaries for clinical trials
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DOI：
10.1016/s0169-2607(99)00037-1
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发表时间：
2000-03-01
影响因子：
6.1
通讯作者：
Gonin, R
中科院分区：
文献类型：
--
作者：
Lazaridis, E;Gonin, R
我们提出了用于计算和评价连续监测停止边界的代码，用于单臂和双臂临床试验。这些设计首先由Thall、Simon和Estey（TSE）（PF）为单组试验开发塔尔河西蒙，E.H. Estey，多结局单组临床试验的贝叶斯序贯监测设计，Stat。14（1995）357-379）。我们的代码纠正了原来的TSE算法中的一些问题，并扩展了这些算法用于双臂试验设置。它是用S-Plus编写的，以提高统计熟练用户的交互性，并采用外部例程，动态加载到S-Plus中，以提高计算效率。我们的代码的有效版本需要C编译器和S-Plus程序。我们的代码已经在UNIX和Microsoft Windows环境中进行了测试，编译代码可以从我们的网站上获得。一个数值积分程序的卷积β分布包括在内。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
We present code for the calculation and evaluation of continuously monitored stopping boundaries for use in one-arm and two-arm clinical trials. These designs were first developed for one-arm trials by Thall, Simon and Estey (TSE) (P.F. Thall, R. Simon, E.H. Estey, Bayesian sequential monitoring designs for single-arm clinical trials with multiple outcomes, Stat. Med. 14 (1995) 357-379). Our code corrects some problems in the original TSE algorithms and extends these algorithms for use in a two-arm trial setting. It is written in S-Plus to improve interactivity for the statistically adept user, and employs external routines, dynamically loaded into S-Plus, to improve calculation efficiency. Efficient versions of our code require both a C compiler and the S-Plus program. Our code has been tested in UNIX and Microsoft Windows environments, and compiled code is available from our website. A numerical integration routine for the convolution of beta distributions is included. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.