Differential Age-Related Bone Architecture Changes between Female and Male STR/Ort Mice
Differential Age-Related Bone Architecture Changes between Female and Male STR/Ort Mice
复制标题
DOI：
10.1538/expanim.61.59
复制
发表时间：
2012-01-01
影响因子：
2.4
通讯作者：
Takaso, Masashi
中科院分区：
文献类型：
--
作者：
Uchida, Kentaro;Urabe, Ken;Takaso, Masashi
雌性STR/Ort小鼠自发性骨关节炎(OA)的发病率远低于雄性STR/Ort小鼠，但其发病率性别差异的原因尚不清楚。在这里，我们调查和比较了雄性和雌性STR/Ort小鼠与年龄和性别相关的骨密度和结构变化。对5、10、15、20、35周龄STR/Ort雄性和雌性STR/Ort小鼠的股骨骨结构和骨密度(BMD)进行显微计算机断层扫描(MU CT)。还测量了5、15和35周龄小鼠的胫骨内扭转角度(ADITT)。雄性STR/Ort小鼠松质骨体积和骨密度较早下降。使用MU CT，在男性和女性中都观察到股骨骨干的骨髓间隙随着年龄的增长而减少，但在女性中更为显著。此外，在雄性STR/Ort小鼠中观察到较早的ADITT增加，这表明胫骨的内旋转可能有助于骨关节炎的发生。雄性和雌性STR/Ort小鼠之间与年龄和性别相关的骨结构变化明显不同。这些骨结构上的差异，特别是ADITT，可能解释了STR/Ort小鼠骨关节炎发生率不同的原因。
The incidence of spontaneous osteoarthritis (OA) in female STR/Ort mice is much lower than that observed in male STR/Ort mice; however, the reason for the differential incidence of OA between sexes has not been elucidated. Here, we investigated and compared age- and sex-related bone mineral density and architectural changes in male and female STR/Ort mice. Bone architecture and bone mineral density (BMD) of femurs were examined in 5-, 10-, 15-, 20-, and 35-week-old male and female STR/Ort mice by microscopic computed tomography (mu CT). Angular degrees of internal tibial torsion (ADITT) were also measured in mice at 5, 15, and 35 weeks of age. Earlier decreases of cancellous volume and BMD were found in male STR/Ort mice. Using mu CT, an age-related decline of bone marrow space in femoral diaphysis was observed in both males and females but was more dramatic in females. In addition, an earlier increase of ADITT was observed in male STR/Ort mice, suggesting that internal rotation of the tibia may contribute to OA. Age- and sex-related bone architectural changes clearly differ between male and female STR/Ort mice. These differences in bone structure, particularly ADITT, may explain the differential incidence of OA in STR/Ort mice.