Genetic referrals of Middle Eastern origin in a western city: Inbreeding and disease profile
Genetic referrals of Middle Eastern origin in a western city: Inbreeding and disease profile
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DOI：
10.1136/jmg.33.3.212
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发表时间：
1996-03-01
影响因子：
4
通讯作者：
Teebi, AS
中科院分区：
文献类型：
--
作者：
Hoodfar, E;Teebi, AS
近亲结婚或近亲结婚是中东文化中常见的传统做法。该地区不同国家和社区的研究表明，频率范围从 20% 到 70% 以上。已知近亲繁殖对发病率和死亡率有不利影响，特别是对于常染色体隐性遗传疾病。这项研究对 200 对夫妇进行了调查，这些夫妇代表了在蒙特利尔大型临床遗传学中心看到的所有中东裔转诊。他们与同一推荐人中规模相似、具有不同文化背景的群体进行了比较。中东群体的跨文化婚姻和近亲繁殖率分别为 24% 和 23.5%，而对照组为 22.5% 和 5%。排除仅因近亲结婚的推荐，研究组中的近亲繁殖率为16.4%。在中东群体中，常染色体隐性遗传病在近交家庭中的发病率是非近交家庭的两倍多，其模式与之前的观察结果一致。
Inbreeding or consanguineous marriage is a common traditional practice in Middle Eastern cultures. Studies from various countries and communities of this region showed that the frequencies range from 20% to greater than 70%. Inbreeding is known to have adverse effects on morbidity and mortality, in particular with respect to autosomal recessive disorders. This study examined 200 couples representing all referrals of Middle Eastern origin seen at a large Clinical Genetics Unit in Montreal. They were compared with a similar sized group of different cultural backgrounds from among the same referrals. The rate of intercultural marriages and inbreeding was found to be 24% and 23.5% respectively in the Middle Eastern group, while they were 22.5% and 5% in the comparison group. Excluding the referrals for consanguinity only, the rate of inbreeding among the study group was 16.4%. Within the Middle Eastern group, autosomal recessive disorders were more than twice as common in the inbred than in the noninbred families, the pattern of which is consistent with previous observations.