Experience-Dependent Reorganization Drives Development of a Binocularly Unified Cortical Representation of Orientation
Experience-Dependent Reorganization Drives Development of a Binocularly Unified Cortical Representation of Orientation
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DOI：
10.1016/j.neuron.2020.04.022
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发表时间：
2020-07-22
期刊：
影响因子：
16.2
通讯作者：
Fitzpatrick, David
中科院分区：
文献类型：
--
作者：
Chang, Jeremy T.;Whitney, David;Fitzpatrick, David
在感觉区域，神经微回路将信息流整合成外部世界的统一表征。在食肉动物的视觉皮层，眼睛特定的输入第一次收敛，它已被假定为一个单一的，双眼对齐的模块化方向表示独立的感官经验的发展。在这项研究中，雪貂视觉皮层使用在体内钙成像，我们发现了不同的发展过程的证据。在发育早期，对侧，同侧，或双眼刺激每个产生组织良好的模块表示的方向，显示功能的成熟皮层。然而，这些表示的比较揭示了相当大的错位，这是明显的模块化和细胞尺度。经验依赖的过程驱动重组这三个表征向一个单一的双眼对齐表示类似于早期的双眼表示通过细胞取向偏好的转变。因此，虽然方向偏好的有序模块网络最初独立于视觉经验出现，但经验对于这些早期表征的对齐至关重要。
Across sensory areas, neural microcircuits consolidate streams of information into unified representations of the external world. In the carnivore visual cortex, where eye-specific inputs first converge, it has been posited that a single, binocularly aligned modular orientation representation develops independent of sensory experience. In this study of ferret visual cortex using in vivo calcium imaging, we find evidence for a different developmental process. Early in development, contralateral, ipsilateral, or binocular stimulation each yield well-organized modular representations of orientation that display features of mature cortex. However, comparison of these representations reveals considerable misalignment that is evident at both modular and cellular scales. Experience-dependent processes drive reorganization of these three representations toward a single binocularly aligned representation resembling the early binocular representation through shifts in cellular orientation preference. Thus, while orderly modular networks of orientation preference initially arise independent of visual experience, experience is critical for the alignment of these early representations.