Treatment of neuroendocrine tumors with somatostatin analogs
Treatment of neuroendocrine tumors with somatostatin analogs
复制标题
用生长抑素类似物治疗神经内分泌肿瘤
作者：
E. T. Janson
神经内分泌肿瘤是一组起源于不同器官的神经内分泌细胞产生激素的肿瘤。大多数肿瘤的Ki67增殖指数较低，肿瘤进展缓慢。然而，许多患者因肿瘤细胞产生和释放的激素而出现内分泌症状。对于一些患者，这些症状可能会危及生命，如中肠类癌患者出现广泛的潮红和低血压，或由产生血管肠多肽的肿瘤引起的严重腹泻。在许多其他患者中，激素引起的症状干扰了进行日常活动的能力。在这些激素相关症状的治疗中引入生长抑素类似物，使大多数症状得以控制，并显著提高了这组患者的生活质量。遗憾的是，临床对肿瘤生长的抑制效果不是很好，只有5-10%的患者表现出客观的反应。然而，在相当数量的患者中可以实现肿瘤生长的稳定。在未来，我们希望新的生长抑素类似物的发展具有更广泛的受体结合谱，将为我们提供新的类似物，在抗增殖作用方面更有效。这种可能性将在未来的试验中进行研究。
Neuroendocrine tumors constitute a group of hormone producing tumors originating from neuroendocrine cells in different organs. Most tumors have a low proliferation index measured by Ki67 and the progression of the tumor is slow. However, many patients suffer from endocrine symptoms induced by the hormones produced and released by the tumor cells. For some patients these symptoms can be life- threatening as in midgut carcinoid patients suffering from carcinoid crises with extensive flushes and hypotension or in patients with severe diarrhea induced by tumors producing vasointestinal polypeptide. In many other patients the hormone-induced symptoms interfere with the ability to carry out ordinary daily activities. The introduction of somatostatin analogs in the treatment of these hormone related symptoms has made it possible to control most of them and has added significantly to the quality of life for this group of patients. Unfortunately, the clinical inhibitory effect on tumor growth has not been very good with only 5–10% of the patients showing an objective response. However, stabilization of tumor growth may be achieved in a significant number of patients. In the future, the hope is that development of new somatostatin analogs with broader receptor-binding profiles will give us new analogs which are more efficient with regard to their antiproliferative effect. This possibility will be studied in future trials.
影响因子：
158.5
作者：
KVOLS, LK;MOERTEL, CG;HAHN, RG
通讯作者：
HAHN, RG
胰腺霍乱综合征：合成生长抑素类似物对肠道水和离子运输的影响。
影响因子：
39.2
作者：
Santangelo,WC;O'Dorisio,TM;Kim,JG;Severino,G;Krejs,GJ
通讯作者：
Krejs,GJ