Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats
Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats
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DOI：
10.1213/01.ane.0000189554.41095.98
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发表时间：
2006-01-01
影响因子：
5.7
通讯作者：
Arslan, G
中科院分区：
文献类型：
--
作者：
Pirat, A;Zeyneloglu, P;Arslan, G
本研究旨在探讨辛伐他汀预处理对大鼠肠缺血再灌注（I/R）所致急性肺损伤的影响。将24只动物随机分配至3个相等组（假手术组、对照组和辛伐他汀组）。辛伐他汀组给予辛伐他汀10 mg（.）kg（-1）（.）第（-1）天，持续3天，而其他组接受安慰剂。辛伐他汀组和对照组分别行上级肠系膜动脉阻断60 min和再灌注90 min。与辛伐他汀组相比，对照组表现出更严重的肠I/R诱导的急性肺损伤，表现为较低的PaO 2和氧饱和度（分别为P = 0.01和P = 0.005）和肺中性粒细胞浸润的平均值较高（P = 0.003）、总肺组织病理学损伤评分（P = 0.003）、肺湿干重比（P = 0.009）和肺组织丙二醛水平（P = 0.016）。对照组和辛伐他汀组在所有测量中的血清水平和支气管肺泡灌洗液中细胞因子（白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α）和P-选择素水平相似，但对照组支气管肺泡灌洗液中P-选择素水平显著较高（P = 0.006）。辛伐他汀预处理可减轻肠I/R大鼠急性肺损伤的严重程度。
In this rat model study we evaluated whether Pretreatment with simvastatin affects the severity of acute lung injury caused by intestinal ischemia-reperfusion (I/R). Twenty-four animals were randomly allocated to three equal groups (sham, control, simvastatin). The simvastatin group was pretreated with simvastatin 10 mg (.) kg(-1) (.) day(-1) for 3 days, whereas the other groups received placebo. The simvastatin and control groups underwent 60 min of superior mesenteric artery occlusion and 90 min of reperfusion. Compared with the simvastatin group, the control group exhibited significantly more severe intestinal I/R-induced acute lung injury, as indicated by lower PaO2 and oxygen saturation (P = 0.01 and P = 0.005, respectively) and higher mean values for neutrophil infiltration of the lungs (P = 0.003), total lung histopathologic injury score (P = 0.003), lung wet-to-dry weight ratio (P = 0.009), and lung-tissue malondialdehyde levels (P = 0.016). The control and simvastatin groups had similar serum levels and similar bronchoalveolar lavage fluid levels of cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and P-selectin at all measurements, except for a significantly higher level of bronchoalveolar lavage fluid P-selectin in the control group (P = 0.006). Pretreatment with simvastatin reduces the severity of acute lung injury induced by intestinal I/R in rats.