Membrane manipulations by the ESCRT machinery.
Membrane manipulations by the ESCRT machinery.
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DOI：
10.12688/f1000research.6319.1
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Odorizzi G
中科院分区：
文献类型：
--
作者：
Odorizzi G
转运所需的内体分选复合物（ESCRT）共同构成了一种机制，该机制最初因其在真核细胞的内吞途径中降解跨膜蛋白的功能而为人所知。然而，自从它们被发现以来，ESCRT已被认为在质膜上发挥重要作用，这似乎是ESCRT机制的原始功能位点。本文回顾了一些主要的研究结果，塑造了我们目前的理解如何ESCRT机器控制膜动力学，并认为ESCRT机器，可能是由这些机制驱动的新角色。
The endosomal sorting complexes required for transport (ESCRTs) collectively comprise a machinery that was first known for its function in the degradation of transmembrane proteins in the endocytic pathway of eukaryotic cells. Since their discovery, however, ESCRTs have been recognized as playing important roles at the plasma membrane, which appears to be the original site of function for the ESCRT machinery. This article reviews some of the major research findings that have shaped our current understanding of how the ESCRT machinery controls membrane dynamics and considers new roles for the ESCRT machinery that might be driven by these mechanisms.