The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli.
The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli.
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DOI：
10.1152/nips.01468.2003
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发表时间：
2003-12
期刊：
影响因子：
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通讯作者：
R. O'neil;Rachel C Brown
中科院分区：
文献类型：
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作者：
R. O'neil;Rachel C Brown
钙渗透通道的TRPV亚家族广泛分布于从线虫到哺乳动物的感觉细胞和非感觉细胞中。这些通道可以被不同范围的刺激（渗透/机械应力，有毒化学物质和热量，内源性介质）不同地激活，这些刺激通常汇聚在同一通道上。有证据表明，TRPV通道是多种微环境刺激的新型“分子整合器”。
The TRPV subfamily of calcium-permeable channels is widely distributed in sensory and nonsensory cells from nematodes to mammals. These channels can be variably activated by a diverse range of stimuli (osmotic/mechanical stress, noxious chemicals and heat, endogenous mediators) that often converge on the same channel. Evidence is presented that TRPV channels function as novel "molecular integrators" of diverse microenvironmental stimuli.