Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats.
Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats.
复制标题
DOI：
10.1254/jphs.13045fp
复制
发表时间：
2013
影响因子：
3.5
通讯作者：
Nishiyama A
中科院分区：
文献类型：
--
作者：
Ohnishi K;Murase M;Nakano D;Pelisch N;Hitomi H;Kobori H;Morimoto S;Mori H;Masaki T;Ohmori K;Kohno M;Ichihara A;Nishiyama A
血管紧张素II（Ang II）输注到大鼠体内通过肾脏中的AT 1受体依赖性途径升高局部血管紧张素II水平。我们研究了血管紧张素转换酶（ACE）抑制剂替莫普利或AT 1受体阻滞剂奥美沙坦治疗是否可预防血管紧张素I（Ang I）输注大鼠肾脏中Ang II水平升高。给大鼠输注Ang I（100 ng/min），并分别给予替莫普利（30 mg/kg/d，n = 10）或奥美沙坦（10 mg/kg/d，n = 9）治疗4周。血管紧张素I输注显着升高血压相比，车辆输注大鼠（n = 6）。用替莫普利或奥美沙坦治疗可抑制Ang I诱导的高血压。替莫普利抑制血浆和肾脏ACE活性。血管紧张素Ⅰ可增加肾脏血管紧张素Ⅱ的含量。有趣的是，替莫普利未能降低肾脏中的Ang II水平，而奥美沙坦显著抑制肾脏Ang II水平的升高。这些结果表明，限制的替莫普利和奥美沙坦抑制肾脏的肾素-血管紧张素系统的好处，并建议可能存在的血管紧张素转换酶不敏感的途径，增加血管紧张素II水平在大鼠肾脏。
Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor–dependent pathway in the kidney. We examined whether treatment with an angio-tensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor blocker, olmesartan, prevented elevation of Ang II levels in the kidney of angiotensin I (Ang I)-infused rats. Rats were infused with Ang I (100 ng/min) and treated with temocapril (30 mg/kg per day, n = 10) or olmesartan (10 mg/kg per day, n = 9) for 4 weeks. Ang I infusion significantly elevated blood pressure compared with vehicle-infused rats (n = 6). Treatment with temocapril or olmesartan suppressed Ang I–induced hypertension. Temocapril suppressed both plasma and renal ACE activity. Ang I infusion increased Ang II content in the kidney. Interestingly, temocapril failed to reduce the level of Ang II in the kidney, while olmesartan markedly suppressed an increase in renal Ang II levels. These results suggest a limitation of temocapril and a benefit of olmesartan to inhibit the renal renin–angiotensin system and suggest the possible existence of an ACE inhibitor–insensitive pathway that increases Ang II levels in rat kidney.
登录
查看更多内容
影响因子：
3.5
作者：
Fan YY;Nishiyama A;Fujisawa Y;Kobori H;Nakano D;Matsuura J;Hase N;Hitomi H;Kiyomoto H;Urata H;Kohno M
通讯作者：
Kohno M
影响因子：
19.6
作者：
Nishiyama, A;Yoshizumi, M;Abe, Y
通讯作者：
Abe, Y
DOI：
10.1152/ajprenal.00213.2012
发表时间：
2012-09-01
影响因子：
4.2
作者：
Kittikulsuth, Wararat;Pollock, Jennifer S.;Pollock, David M.
通讯作者：
Pollock, David M.
影响因子：
3.5
作者：
Lei B;Nakano D;Fan YY;Kitada K;Hitomi H;Kobori H;Mori H;Masaki T;Nishiyama A
通讯作者：
Nishiyama A
影响因子：
3.7
作者：
Ahmad S;Simmons T;Varagic J;Moniwa N;Chappell MC;Ferrario CM
通讯作者：
Ferrario CM