Childhood central nervous system infections and risk for schizophrenia
Childhood central nervous system infections and risk for schizophrenia
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DOI：
10.1007/s00406-004-0485-2
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发表时间：
2004-02-01
影响因子：
4.7
通讯作者：
Isohanni, M
中科院分区：
文献类型：
--
作者：
Koponen, H;Rantakallio, P;Isohanni, M
中枢神经系统（CNS）病毒感染被认为会增加精神分裂症的风险，尽管大多数证据是间接的，并且来自于对暴露于各种感染的研究。在芬兰北方1966年出生队列中，分析了精神分裂症和其他精神病与儿童中枢神经系统感染之间的关系，本文介绍了截至1994年底和1997年底的随访结果。使用DSM-III-R分类对登记的精神病诊断进行验证。在11017例受试者中（占当年所有出生人数的96%），145例在儿童期患有CNS感染，其中102例为病毒感染。在1994年底的随访中，76人患有精神分裂症，到1997年底，他们的人数增加到100人。此外，截至一九九四年年底为止，有52名病人并非精神分裂症，其中4名精神分裂症病人及没有其他精神病病人曾受病毒感染。没有精神分裂症病例和两名其他精神病患者有细菌感染。在1994年底的随访中，病毒性CNS感染后精神分裂症的校正比值比为4.8（95%置信区间[CI] 1.6-14.0），在1997年底的随访中为2.5（0.9-7.0）。临床病程变量之间没有显着差异的精神分裂症患者有或无CNS感染。我们的研究结果表明，病毒性CNS感染在儿童期可能有一个角色作为精神分裂症的危险因素。由于其相对稀少，它们在种群水平上的作用可能不大。
Central nervous system (CNS) viral infections have been suggested to increase the risk of schizophrenia, although most of the evidence is indirect and comes from rather few studies on exposure to various infections in general. In the Northern Finland 1966 Birth Cohort the association between schizophrenia and other psychoses and childhood CNS infections has been analysed, and in this paper we present the follow-up results up to the end of 1994 and 1997.Data regarding the infections were collected prospectively between 1966-1980 and data on psychoses from 1982. The registered psychiatric diagnoses were validated using the DSM-III-R classification. Out of the 11017 subjects (96% of all births in that year) 145 had suffered a CNS infection during childhood, which in 102 cases was a viral infection. In the follow-up to the end of 1994,76 had schizophrenia, and their number increased to 100 to the end of 1997. In addition, up to the end of 1994,52 patients had a non-schizophrenic psychosis.Four cases in the schizophrenia patient group and none of the patients with other psychosis had suffered a viral CNS infection. None of the schizophrenia cases and two of the patients with other psychosis had had a bacterial infection. The adjusted odds ratio for schizophrenia after a viral CNS infection was 4.8 (95% confidence intervals [CI] 1.6-14.0) in the follow-up to the end of 1994 and 2.5 (0.9-7.0) in the follow-up to the end of 1997. The clinical course variables did not differ between the schizophrenia patients with or without CNS infection.Our results suggest that viral CNS infections during childhood may have a role as a risk factor for schizophrenia. Their role may be modest at the population level due to their relative rareness.