Marine omega-3 fatty acid intake: associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study.
Marine omega-3 fatty acid intake: associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study.
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DOI：
10.2337/dc09-1235
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发表时间：
2010-01
期刊：
影响因子：
16.2
通讯作者：
Look AHEAD (Action for Health in Diabetes) Obesity, Inflammation, and Thrombosis Research Group
中科院分区：
文献类型：
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作者：
Belalcazar LM;Reboussin DM;Haffner SM;Reeves RS;Schwenke DC;Hoogeveen RC;Pi-Sunyer FX;Ballantyne CM;Look AHEAD (Action for Health in Diabetes) Obesity, Inflammation, and Thrombosis Research Group
To examine usual marine ω-3 fatty acid (mO-3FA) intake in individuals with diabetes; its association with adiposity, lipid, and glucose control; and its changes with behavioral lifestyle intervention for weight loss. Cross-sectional and 1-year longitudinal analyses were performed on 2,397 Look AHEAD (Action for Health in Diabetes) participants. Look AHEAD is a cardiovascular outcome trial evaluating the effects of intensive lifestyle intervention for weight loss in overweight/obese subjects with type 2 diabetes. Baseline mO-3FA intake was 162 ± 138 mg/day. It was inversely associated with triglycerides (β = −0.41, P < 0.001) and weakly with HDL (β = 4.14, P = 0.050), after multiple covariate adjustment. One-year mO-3FA and fried/sandwich fish intake decreased with intensive lifestyle intervention (P < 0.001). mO-3FA intake in Look AHEAD participants was low but associated favorably with lipids. These results encourage investigation on the potential benefits of increasing mO-3FA intake in lifestyle interventions for weight loss in individuals with diabetes.
