ATHEROSCLEROSIS IN LEMMINGS AND VOLES FED A HIGH-FAT, HIGH CHOLESTEROL DIET
ATHEROSCLEROSIS IN LEMMINGS AND VOLES FED A HIGH-FAT, HIGH CHOLESTEROL DIET
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DOI：
10.1016/0021-9150(79)90115-1
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发表时间：
1979-01-01
期刊：
影响因子：
5.3
通讯作者：
PRESTON, DJ
中科院分区：
文献类型：
--
作者：
DIETERICH, RA;PRESTON, DJ
2种旅鼠和2种狐猴。的田鼠被喂养了几个月的高脂肪、高胆固醇的食物。克氏隐翅虫为中度(2.time)血清胆固醇升高，而东方田鼠显著升高(5倍)，史蒂文森氏田鼠和红缘田鼠极显著升高(8倍)。和11次)。在所有物种中都可以看到典型的动脉粥样硬化病变，但红蜘蛛的病变明显更严重。在这些自发死亡的实验鼠中，除动脉粥样硬化外，肝脏脂肪浸润是主要的病理损害。
Two species of lemmings and 2 spp. of voles were fed a high fat, high cholesterol diet for several months. Clethrionomys rutilus had a moderate (2 .times.) rise in serum cholesterol while Microtus oeconomus had a marked increase (5 .times.); Dicrostonyx stevensoni and Dicrostonyx rubricatus had extreme increases (8 .times. and 11 .times., respectively). Typical atherosclerotic lesions were seen in all species but D. rubricatus had significantly more severe lesions. Hepatic fatty infiltration was the principal pathologic lesion found besides atherosclerosis in those test rodents which died spontaneoously.