Grid cells encode local head direction
Grid cells encode local head direction
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DOI：
10.1101/681312
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发表时间：
2019-06
期刊：
影响因子：
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通讯作者：
Klara Gerlei;Jessica Passlack;Ian Hawes;Brianna Vandrey;Holly Stevens;Ioannis Papastathopoulos;M. Nolan
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文献类型：
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作者：
Klara Gerlei;Jessica Passlack;Ian Hawes;Brianna Vandrey;Holly Stevens;Ioannis Papastathopoulos;M. Nolan
网格和头部方向代码代表导航和记忆的认知空间。纯网格单元生成的网格代码被假定为独立于头部方向，而合取单元生成的网格表示被调整到一个单一的头部方向。在这里，我们证明了纯网格细胞也编码头部方向，但通过不同的机制。我们表明，纯网格细胞的个人射击场被调谐到多个头部方向，与不同领域之间的首选方向集。这种局部方向性不是由以前的连续吸引子或振荡干扰模型的网格发射预测，但占模型中，纯网格细胞整合输入从共同对齐的合取细胞与不同的发射率，他们的领域。来自网格单元的局部方向信号可以通过对来自相同位置的不同视点进行解相关来有助于下游计算。
Grid and head direction codes represent cognitive spaces for navigation and memory. Pure grid cells generate grid codes that have been assumed to be independent of head direction, whereas conjunctive cells generate grid representations that are tuned to a single head direction. Here, we demonstrate that pure grid cells also encode head direction, but through distinct mechanisms. We show that individual firing fields of pure grid cells are tuned to multiple head directions, with the preferred sets of directions differing between fields. This local directionality is not predicted by previous continuous attractor or oscillatory interference models of grid firing but is accounted for by models in which pure grid cells integrate inputs from co-aligned conjunctive cells with firing rates that differ between their fields. Local directional signals from grid cells may contribute to downstream computations by decorrelating different points of view from the same location.