Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma
Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma
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DOI：
10.1046/j.1365-2559.2001.01283.x
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发表时间：
2001-12-01
期刊：
影响因子：
6.4
通讯作者：
Sasaki, K
中科院分区：
文献类型：
--
作者：
Liu, XP;Kawauchi, S;Sasaki, K
目的：为了评估p27（Kip1）、p21（Waf1/Cip1）和p53单独或联合在胃癌中的预后价值，我们用免疫组织化学方法研究了p27（Kip1）、p21（Waf1/Cip1）和p53蛋白在胃癌中的表达。方法与结果：采用免疫组化方法检测140例胃癌组织中p27（Kip1）、p21（Waf1/Cip1）、p53的表达。P27（Kip1）和p21（Waf1/Cip1）阳性表达与预后良好相关(P
Aims: In order to estimate the prognostic values of p27(Kip1), p21(Waf1/Cip1), and p53, alone and in combination, we investigated immunohistochemically the expression of p27(Kip1), p21(Waf1/Cip1), and p53 proteins in gastric carcinomas.Methods and results: The expression of p27(Kip1), p21(Waf1/Cip1), and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of P27(Kip1) and p21(Waf1/Cip1) correlated significantly with a favourable prognosis (P