Efficient construction of C–S and C–N bonds via metal-free reductive coupling of N-tosylhydrazones with benzo[d]thiazole-2-thiol
Efficient construction of C–S and C–N bonds via metal-free reductive coupling of N-tosylhydrazones with benzo[d]thiazole-2-thiol
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DOI：
10.1039/c4ra00590b
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发表时间：
2014-04
期刊：
影响因子：
3.9
通讯作者：
Yuqin Lin;Puying Luo;Q. Zheng;Yu-Mei Liu;Xiaoyan Sang;Q. Ding
中科院分区：
文献类型：
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作者：
Yuqin Lin;Puying Luo;Q. Zheng;Yu-Mei Liu;Xiaoyan Sang;Q. Ding
通过n -甲酰基腙与苯并[d]噻唑-2-硫醇的无金属还原偶联，建立了一种合成多种苯并[d]噻唑衍生物的高效方法。2-硫代苯并噻唑是一种有用的合成中间体和有前景的生物活性化合物。本工艺适用于各种底物，效率高，选择性适中。
An efficient procedure for the synthesis of diverse benzo[d]thiazole derivatives has been developed via metal-free reductive coupling of N-tosylhydrazones with benzo[d]thiazole-2-thiols. 2-Thio-substituted benzothiazoles are useful synthetic intermediates and promising biologically active compounds. The present process tolerates a wide range of substrates with high efficiency and moderate selectivity.