Vascular abnormalities in patients with Stargardt disease assessed with optical coherence tomography angiography
Vascular abnormalities in patients with Stargardt disease assessed with optical coherence tomography angiography
复制标题
DOI：
10.1136/bjophthalmol-2016-308869
复制
发表时间：
2017-06-01
影响因子：
4.1
通讯作者：
Bandello, Francesco
中科院分区：
文献类型：
--
作者：
Parodi, Maurizio Battaglia;Cicinelli, Maria Vittoria;Bandello, Francesco
目的通过光学相干断层扫描血管造影术（OCT-A）描述Stargardt病（STGD 1）患者的血管异常。方法横断面病例系列，纳入标准为：STGD 1的诊断、清晰的眼介质和稳定的固定。患者接受了最佳矫正视力（BCVA）、生物显微镜检查、压平眼压测量、短波眼底自发荧光（SW-FAF）（HRA Heidelberg，德国）、3x 3扫描源OCT-A（Topcon Corporation，日本）。人工勾画中央凹无血管区（FAZ）区域，并从血管密度分析（ImageJ）中删除。主要观察STGD 1患者的浅表毛细血管丛（SCP）、深毛细血管丛（DCP）和脉络膜毛细血管丛（CC）的血管密度。平均年龄为33 ± 5.7岁，平均BCVA为0.6 ± 0.3最小分辨率角的对数。36名年龄匹配的健康受试者（每例患者一只眼睛）作为对照组。OCT-A的定性分析显示浅表和DCP中血管密度降低的区域。CC显示局灶性缺损，部分对应于SW-FAF成像上的皮瓣。OCT-A的定量分析揭示了SCP密度（0.302 +/- 0.062 vs 0.365 +/- 0.042; p=0.0002）和DCP密度（0.303 +/- 0.081 vs 0.399 +/- 0.045; p
Aims To describe the vascular abnormalities in patients affected by Stargardt disease (STGD1) by means of optical coherence tomography angiography (OCT-A).Methods Cross-sectional case series, with the following inclusion criteria: diagnosis of STGD1, clear ocular media, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, applanation tonometry, short-wavelength fundus autofluorescence (SW-FAF) (HRA Heidelberg, Germany), 3x3 Swept Source OCT-A (Topcon Corporation, Japan). Foveal avascular zone (FAZ) area was manually outlined and removed from the vessel density analysis (ImageJ). Main outcome was vessel density assessment in the superficial capillary plexus (SCP), in the deep capillary plexus (DCP), and in the choriocapillaris (CC) of patients with STGD1.Results Nineteen patients (36 eyes) were recruited for the study (10 females, 52.6%). Mean age was 33 +/- 5.7 years and mean BCVA was 0.6 +/- 0.3 logarithm of the minimum angle of resolution. Thirty-six healthy age-matched subjects (one eye for each patient) acted as a control group. Qualitative analysis of OCT-A revealed areas of reduced vascular density in superficial and DCPs. CC showed focal defects partially corresponding to the flecks on SW-FAF imaging. Quantitative analysis of OCT-A disclosed a statistically significant difference in the density of the SCP (0.302 +/- 0.062 vs 0.365 +/- 0.042; p=0.0002) and the DCP (0.303 +/- 0.081 vs 0.399 +/- 0.045; p