COLONIC FERMENTATION OF DIETARY FIBER TO SHORT CHAIN FATTY-ACIDS IN PATIENTS WITH ADENOMATOUS POLYPS AND COLONIC-CANCER
COLONIC FERMENTATION OF DIETARY FIBER TO SHORT CHAIN FATTY-ACIDS IN PATIENTS WITH ADENOMATOUS POLYPS AND COLONIC-CANCER
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DOI：
10.1136/gut.32.8.923
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发表时间：
1991-08-01
期刊：
影响因子：
24.5
通讯作者：
MORTENSEN, PB
中科院分区：
文献类型：
--
作者：
CLAUSEN, MR;BONNEN, H;MORTENSEN, PB
短链（C2-C6）脂肪酸是在结肠中通过主要是膳食纤维的细菌发酵产生的。丁酸酯（C4）对人结肠癌细胞具有抑制作用，流行病学研究表明高纤维饮食可降低结肠癌的发病率。因此，膳食纤维在结直肠癌发生过程中的作用可能与其发酵成丁酸有关。粪便中总短链脂肪酸的浓度和个别C2-C6脂肪酸的浓度和比例之间没有差异16名健康对照，17名结肠腺瘤患者，17名结肠癌患者。葡萄糖，ispagula，麦麸，白蛋白在6和24小时的粪便培养的总的和个人的短链脂肪酸的摩尔生产速度（mmol/L.小时）的比较显示没有差异。然而，与健康对照组相比，结肠癌和腺瘤患者的丁酸产量与总短链脂肪酸产量的比值降低（ispagula，6小时：分别为6.4、7.6和11.5%，p = 0.005，24小时：9.1、9.9和15.4%，p = 0.002;麦麸，6小时：分别为9.9、10.2和14.7%，p = 0.06和24小时：15.1、16.8和21.0%，p = 0.01）。这可能是因为结肠丁酸盐形成的低比率与低纤维饮食相结合增加了结肠肿瘤的风险。
Short chain (C2-C6) fatty acids are produced in the colon through bacterial fermentation of mainly dietary fibre. Butyrate (C4) possesses antineoplastic effects on human colon carcinoma cells, and epidemiological studies indicate that high fibre diets may reduce the incidence of colorectal cancer. The role of dietary fibre during colorectal carcinogenesis might therefore be related to its fermentation to butyrate. Faecal concentrations of total short chain fatty acids and concentrations and ratios of the individual C2-C6 fatty acids did not differ between 16 healthy controls, 17 patients with colonic adenomas, and 17 patients with colonic cancer. Comparison of the molar production velocities (mmol/l.hour) of total and individual short chain fatty acids from glucose, ispagula, wheat bran, and albumin in six and 24 hour faecal incubations showed no differences. The ratio of butyrate production to total short chain fatty acid production from fibre, however, was reduced in patients with colonic cancer and adenomas compared with healthy controls (ispagula, six hours: 6.4, 7.6, and 11.5% respectively, p = 0.005 and 24 hour: 9.1, 9.9, and 15.4%, p = 0.002; wheat bran, six hours: 9.9, 10.2, and 14.7% respectively, p = 0.06 and 24 hours: 15.1, 16.8, and 21.0%, p = 0.01). It may be that the low ratios of colonic butyrate formation combined with low fibre diets increase the risk of colonic neoplasia.