ssDNA viruses: key players in global virome
ssDNA viruses: key players in global virome
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DOI：
10.1007/s13337-019-00519-4
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发表时间：
2019-03-01
期刊：
影响因子：
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通讯作者：
Devi, P. Renuka
中科院分区：
文献类型：
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作者：
Malathi, V. G.;Devi, P. Renuka
单链（ss）DNA病毒非常广泛，感染来自所有三个生命领域的不同宿主，并且包括重要的病原体。大多数ssDNA病毒具有小的基因组，其通过由不同的病毒编码的核酸内切酶启动的滚环样机制进行复制。高通量基因组测序和改进的生物信息学工具已经产生了大量关于不同栖息地中ssDNA病毒存在的信息。ssDNA病毒的简单基因组具有高度的突变和重组倾向，经常对人类文明构成威胁。有趣的是，它们的基因组被发现嵌入在可以追溯到百万年前的化石中。ssDNA病毒不同寻常的进化历史揭示了基因水平转移的证据，有时在不同的物种和属之间。
Single-stranded (ss)DNA viruses are extremely widespread, infect diverse hosts from all three domains of life and include important pathogens. Most ssDNA viruses possess small genomes that replicate by the rolling-circle-like mechanism initiated by a distinct virus-encoded endonuclease. High throughput genome sequencing and improved bioinformatics tools have yielded vast information on presence of ssDNA viruses in diverse habitats. The simple genome of ssDNA viruses have high propensity to undergo mutation and recombination often emerging as threat to human civilization. Interestingly their genome is found embedded in fossils dating back to million years. The unusual evolutionary history of ssDNA viruses reveal evidences of horizontal gene transfer, sometimes between different species and genera.