The systemic response to lung infection
The systemic response to lung infection
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DOI：
10.1016/j.ccm.2004.10.009
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发表时间：
2005-03-01
影响因子：
5.7
通讯作者：
Standiford, TJ
中科院分区：
文献类型：
--
作者：
Deng, JC;Standiford, TJ
宿主对肺部微生物入侵的反应必须足够强烈，以允许微生物根除，但适当控制以防止反应溢出到体循环。尽管肺炎的炎症反应通常是区隔化的，但微生物和宿主因素可促进对肺部感染的紊乱全身反应。评估肺炎全身性炎症反应的强度的临床价值有限，抑制这种反应的尝试未能改善临床结果。在脓毒症和其他危重疾病中发生的全身炎症反应可严重损害肺部先天和获得性免疫。危重疾病引起的免疫麻痹的机制尚未完全确定，是正在进行的临床和基础研究的重点。
The host response to microbial invasion in the lung must be sufficiently vigorous to allow for microbial eradication but appropriately controlled to prevent spillover of the response into the systemic circulation. Although inflammatory responses in pneumonia are generally compartmentalized, microbial and host factors can promote disordered systemic responses to lung infection. Assessment of the magnitude of the systemic inflammatory response in pneumonia is of limited clinical value, and attempts to suppress this response have failed to improve clinical outcomes. The systemic inflammatory response that occurs in sepsis and other critical illnesses can substantially impair lung innate and acquired immunity. Mechanisms of critical illness-induced immunoparalysis have been incompletely characterized and are the focus of ongoing clinical and basic investigations.