Developmental changes in eye-blink conditioning and neuronal activity in the cerebellar interpositus nucleus
Developmental changes in eye-blink conditioning and neuronal activity in the cerebellar interpositus nucleus
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DOI：
10.1523/jneurosci.20-02-00813.2000
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发表时间：
2000-01-15
影响因子：
5.3
通讯作者：
Nicholson, DA
中科院分区：
文献类型：
--
作者：
Freeman, JH;Nicholson, DA
在经典的眨眼反应条件反射过程中，记录了幼年大鼠小脑间置核的神经元活动。眨眼条件反应的百分比和幅度随着出生后年龄的增加而增加。小脑中的学习特异性神经元活动与眨眼条件反应并行出现在个体发育中。在条件性刺激和非条件性刺激开始后，神经元活动也有年龄特异性的变化。结果表明，眨眼条件反应的发展可能依赖于小脑中刺激诱发的神经元反应和学习特异性可塑性的发展。传入神经通路的功能不成熟可能会限制小脑神经可塑性的诱导，从而限制眨眼条件反应的发展。
Neuronal activity was recorded in the cerebellar interpositus nucleus in infant rats during classical conditioning of the eyeblink response. The percentage and amplitude of eye-blink conditioned responses increased as a function of postnatal age. Learning-specific neuronal activity in the cerebellum emerged ontogenetically in parallel with the eye-blink conditioned response. There were also age-specific changes in neuronal activity after the onset of the conditioned and unconditioned stimuli. The results indicate that the development of the eye-blink conditioned response may depend on the development of stimulus-evoked neuronal responses and learning-specific plasticity in the cerebellum. Functional immaturity in the afferent neural pathways may limit the induction of neural plasticity in the cerebellum and thereby limit the development of the eye-blink conditioned response.