Human anterior cingulate cortex neurons modulated by attention-demanding tasks
Human anterior cingulate cortex neurons modulated by attention-demanding tasks
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DOI：
10.1152/jn.2000.83.6.3575
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发表时间：
2000-06-01
影响因子：
2.5
通讯作者：
Dostrovsky, JO
中科院分区：
文献类型：
--
作者：
Davis, KD;Hutchison, WD;Dostrovsky, JO
最近的影像学研究表明，前扣带皮层（ACC）与包括注意力在内的各种认知功能有关。然而，到目前为止，还没有证据表明在执行需要注意力和努力思考的任务时，单个ACC神经元的神经元活动会发生变化。我们假设这些神经元一定存在于人类前扣带皮层中。在这项研究中，我们展示了36个被测试神经元中19%的人ACC的微电极单神经元记录在注意力要求任务中神经元调节的电生理数据。这些发现为认知状态对人类ACC神经元自发神经元活动的影响提供了第一个直接证据。
Recent imaging studies have implicated the anterior cingulate cortex (ACC) in various cognitive functions, including attention. However, until now, there was no evidence for changes in neuronal activity of individual ACC neurons during performance of tasks that require attention and effortful thought. We hypothesized these neurons must exist in the human ACC. In this study, we present electrophysiological data from microelectrode single neuron recordings in the human ACC of neuronal modulation during attention-demanding tasks in 19% of 36 neurons tested. These findings provide the first direct evidence of an influence of a cognitive state on the spontaneous neuronal activity of human ACC neurons.