Stereotactic body radiation therapy for nonmetastatic lung cancer: An analysis of 75 patients treated over 5 years
Stereotactic body radiation therapy for nonmetastatic lung cancer: An analysis of 75 patients treated over 5 years
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DOI：
10.1016/j.ijrobp.2005.11.028
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发表时间：
2006-05-01
影响因子：
7
通讯作者：
Terjanian, Terenig
中科院分区：
文献类型：
--
作者：
Beitler, Jonathan J.;Badine, Edgard A.;Terjanian, Terenig
目的：即使对于可手术切除的患者，非小细胞肺癌（NSCLC）也可能无法进行医学手术。对于拒绝手术或因身体原因无法手术的患者，放射治疗可能是最好的治疗选择。立体定向全身放射治疗 (SBRT) 采用外固定和大分割，向小靶区提供每部分高剂量的放射。方法和材料：对 75 名在史泰登岛大学医院接受治疗超过 5 年的患者进行回顾性分析，作为 NSCLC 或推定 NSCLC 的确定性治疗。患者在 27 天内平均接受 5 次剂量治疗，每次剂量为 8 Gy。结果：总体 1 年、2 年和 5 年精算生存率分别为 63%、45% 和 17%。肿瘤总体积 (GTV) 小于 65 cm(3) 的患者具有较长的中位生存期（25.7 个月与 9.9 个月，p < 0.003），5 年时，GTV 小于 65 cm(3) 的患者精算生存率为 24%，GTV 大于 65 cm(3) 的患者为 0%。结论：立体定向放射治疗无效用于治疗 GTV 大于 65 cm(3) 的患者。 SBRT 对于 GTV 小于 65 cm(3) 的患者很有希望。 (c) 2006 爱思唯尔公司
Purpose: Non-small-cell lung cancer (NSCLC) may not be medically operable even in patients with surgically resectable disease. For patients who either refuse surgery or are medically inoperable, radiation therapy may be the best therapeutic choice. Stereotactic body radiation therapy (SBRT) employs external fixation and hypo-fractionation to deliver a high dose per fraction of radiation to a small target volume.Methods and Materials: Retrospective review of 75 patients treated over 5 years at Staten Island University Hospital as definitive treatment for NSCLC or presumed NSCLC. Patients received a median of 5 fractions of 8 Gy per fraction over 27 days.Results: Overall 1-, 2-, and 5-year actuarial survivals were 63%, 45%, and 17%. Patients with a gross tumor volume (GTV) less than 65 cm(3) enjoyed a longer median survival (25.7 vs. 9.9 months, p < 0.003), and at 5 years, the actuarial survival for the patients with GTVs less than 65 cm(3) was 24% vs. 0% for those with GTVs larger than 65 cm(3).Conclusions: Stereotactic body radiation therapy as delivered was ineffective for curing the patients whose GTVs were larger than 65 cm(3). SBRT was promising for those with GTVs less than 65 cm(3). (c) 2006 Elsevier Inc.