N-heterocyclic carbene-catalyzed tandem aza-benzoin/Michael reactions: on site reversal of the reactivity of N-Boc imines.
N-heterocyclic carbene-catalyzed tandem aza-benzoin/Michael reactions: on site reversal of the reactivity of N-Boc imines.
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DOI：
10.1039/c0cc01769h
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发表时间：
2011-01
影响因子：
4.9
通讯作者：
Ke-Jia Wu;Gongqiang Li;Yi Li;L. Dai;S. You
中科院分区：
文献类型：
--
作者：
Ke-Jia Wu;Gongqiang Li;Yi Li;L. Dai;S. You
串联 NHC 催化的氮杂苯偶姻/迈克尔反应已被开发为一种有效生产二氢茚酮和含吡咯烷酮的三环化合物的方法。新的反应模式涉及叔丁基芳基（甲苯磺酰基）甲基氨基甲酸酯在同一碳上作为亲电子试剂和亲核试剂进行反应。
A tandem NHC-catalyzed aza-benzoin/Michael reaction has been developed as a method to efficiently produce dihydroindenones and pyrrolidinone-containing tricycles. The novel reaction pattern involves tert-butyl aryl(tosyl)methylcarbamates reacting as both electrophile and nucleophile on the same carbon.