Development of Sensory Gamma Oscillations and Cross-Frequency Coupling from Childhood to Early Adulthood
Development of Sensory Gamma Oscillations and Cross-Frequency Coupling from Childhood to Early Adulthood
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DOI：
10.1093/cercor/bht341
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发表时间：
2015-06-01
期刊：
影响因子：
3.7
通讯作者：
Lewis, David A.
中科院分区：
文献类型：
--
作者：
Cho, Raymond Y.;Walker, Christopher P.;Lewis, David A.
鉴于γ振荡在正常和干扰认知中的重要性，对它们的发育轨迹的兴趣越来越大。在当前的研究中，使用听觉稳态反应（ASSR）研究了与年龄相关的感觉皮质伽马的变化，这是索引的皮质活性，这些皮质活性被带到了周期性的听觉刺激中。在20，30和40 Hz点击列车中，大量8-22岁的样本（n = 188）具有脑电图记录，分析了诱发幅度，相锁定因子（PLF）和跨频偶联的振幅（PLF）（PLF）（ CFC）具有较低频率的振荡。 40 Hz诱发的功率和PLF从8个年至16年单调增加，随后降低到20-22岁。 CFC遵循类似的模式，通过Delta振荡阶段，与年龄相关的40 Hz振幅的调制最强。相比之下，20和30 Hz刺激的诱发能力，PLF和CFC与40 Hz的条件不同，从童年到成年初期，均具有平坦或减少的曲线。 γ振荡的倒U形发育轨迹可能与相互作用的相互作用过程一致，例如增加快速GABA抑制作用，从而增强了伽马活性和突触修剪，从而降低了伽马活性，从而可以从童年开始到成年。
Given the importance of gamma oscillations in normal and disturbed cognition, there has been growing interest in their developmental trajectory. In the current study, age-related changes in sensory cortical gamma were studied using the auditory steady-state response (ASSR), indexing cortical activity entrained to a periodic auditory stimulus. A large sample (n = 188) aged 8-22 years had electroencephalography recording of ASSR during 20-, 30-, and 40-Hz click trains, analyzed for evoked amplitude, phase-locking factor (PLF) and cross-frequency coupling (CFC) with lower frequency oscillations. Both 40-Hz evoked power and PLF increased monotonically from 8 through 16 years, and subsequently decreased toward ages 20-22 years. CFC followed a similar pattern, with strongest age-related modulation of 40-Hz amplitude by the phase of delta oscillations. In contrast, the evoked power, PLF and CFC for the 20- and 30-Hz stimulation were distinct from the 40-Hz condition, with flat or decreasing profiles from childhood to early adulthood. The inverted U-shaped developmental trajectory of gamma oscillations may be consistent with interacting maturational processes-such as increasing fast GABA inhibition that enhances gamma activity and synaptic pruning that decreases gamma activity-that may continue from childhood through to adulthood.