Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients
Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients
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DOI：
10.1136/thoraxjnl-2021-218403
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kefang Lai
中科院分区：
文献类型：
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作者：
Jiayang Sun;Chen Zhan;Zheng Deng;Wei Luo;Qiaoli Chen;Mei Jiang;Nanshan Zhong;Kefang Lai
Chronic refractory cough (CRC) is characterised by cough hypersensitivity. Interferon-γ (IFN-γ) has been reported to induce calcium influx, action potentials of vagal neurons in vitro and cough response in guinea pigs. While the effect of IFN-γ in CRC patients remains unknown. Here, via flow-cytometry and inhalation cough challenge, we found CRC patients had significantly increased levels of sputum IFN-γ+CD4+ T cells, IFN-γ+CD8+ T cells as well as supernatant of IFN-γ. The average number of coughs in CRC patients increased as the concentration of inhaled IFN-γ went up in IFN-γ cough challenge. Two or more coughs and five or more coughs elicited by inhaled IFN-γ in CRC patients occurred in 7 of 10 and 2 of 10, respectively. Preinhaled IFN-γ (100 µg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers. Targeting IFN-γ may be a potential effective anti-tussive strategy in CRC patients.
