Noradrenergic function and the cortisol response to dexamethasone in depression

Noradrenergic function and the cortisol response to dexamethasone in depression
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抑郁症中去甲肾上腺素能功能和皮质醇对地塞米松的反应

DOI:
10.1016/0165-1781(85)90034-4
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发表时间:
1985
影响因子:
11.3
通讯作者:
G. Heninger
G. Heninger
中科院分区:
医学2区
文献类型:
--
作者:
A. Rubin;L. Price;D. Charney;G. Heninger

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下丘脑-垂体-肾上腺(HPA)轴和去甲肾上腺素能系统的功能障碍在抑郁症中已有报道。为了研究这两个系统之间可能存在的相互关系,我们比较了64例抑郁症患者血浆游离3-甲氧基-4-羟基苯乙二醇(MPHG)与皮质醇对地塞米松的反应。地塞米松后皮质醇非抑制者的基线血浆游离MHPG值高于皮质醇抑制者。一些抑郁症状的严重程度增加与地塞米松后皮质醇水平增加有关。这些结果表明,抑郁症患者与地塞米松非抑制增加去甲肾上腺素能营业额。
Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis and the noradrenergic system have been reported in depression. To study possible interrelations between these two systems, plasma free 3-methoxy-4-hydroxyphenylglycol (MPHG) was compared with the cortisol response to dexamethasone in 64 depressed patients. Postdexamethasone cortisol nonsuppressors had higher baseline plasma free MHPG values than did cortisol suppressors. Increased severity of some depressive symptoms was associated with increased postdexamethasone cortisol levels. These results indicate that depressed patients with dexamethasone nonsuppression have increased noradrenergic turnover.
DOI: 10.1001/archpsyc.1981.01780260017001
发表时间: 1981
影响因子: --
作者:
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者: B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
DOI: 10.1001/archpsyc.1984.01790190025003
发表时间: 1984-08
影响因子: --
作者:
D. Charney;G. Heninger;A. Breier
通讯作者: D. Charney;G. Heninger;A. Breier
抑郁症的神经内分泌和神经化学测量。
DOI: 10.1176/ajp.138.12.1555
发表时间: 1981
期刊: The American journal of psychiatry
影响因子: --
作者:
Davis,KL;Hollister,LE;Mathe,AA;Davis,BM;Rothpearl,AB;Faull,KF;Hsieh,JY;Barchas,JD;Berger,PA
通讯作者: Berger,PA
DOI: 10.1001/archpsyc.1981.01780370036004
发表时间: 1981
影响因子: --
作者:
Charney,DS;Heninger,GR;Sternberg,DE;Redmond,DE;Leckman,JF;Maas,JW;Roth,RH
通讯作者: Roth,RH