SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2'-DEOXY-4'-THIOPYRIMIDINE NUCLEOSIDES
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2'-DEOXY-4'-THIOPYRIMIDINE NUCLEOSIDES
复制标题
DOI：
10.1021/jm00112a007
复制
发表时间：
1991-08-01
影响因子：
7.3
通讯作者：
MONTGOMERY, JA
中科院分区：
文献类型：
--
作者：
SECRIST, JA;TIWARI, KN;MONTGOMERY, JA
已经合成了2 '-脱氧-4'-硫代胞苷（7-β）、2 '-脱氧-4'-硫代尿苷（9）和4 '-硫代胸苷（10），并在体外评价了细胞毒性。所有这些化合物对L1210、H-Ep-2和CCRF-CEM细胞系均具有细胞毒性。4 '-硫代胸苷在细胞培养物中对单纯疱疹病毒1型和人巨细胞病毒也有活性。
2'-Deoxy-4'-thiocytidine (7-beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.