Planar coil excitation of multifrequency shear wave transducers
Planar coil excitation of multifrequency shear wave transducers
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DOI：
10.1016/j.bios.2004.04.023
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发表时间：
2005-01-15
影响因子：
12.6
通讯作者：
Lowe, CR
中科院分区：
文献类型：
--
作者：
Stevenson, AC;Araya-Kleinsteuber, B;Lowe, CR
用平面螺旋线圈代替声谐振器电极的换能器形式被用来从吸附的蛋白质膜中提取多频光谱信息。非晶态二氧化硅振荡器和晶态压电谐振器都是通过磁场直接产生的力和线圈的电磁场诱导的压电激励穿过气隙而驱动共振的。对6 MHz~0.6 GHz的谐振器频率的检测表明，这两种谐振器的响应由不同的剪切驻波来描述，具有与石英晶体微天平相似的声学特征。将这些设备暴露在蛋白质溶液中会导致它们的谐波频率发生可重复的移位，最高可达15 kHz，并随着频率和工作模式的变化而线性增加。由频率变化与工作频率之比确定的梯度，石英器件为21.5×10~(-6)，二氧化硅器件为60.9×10~(-6)。在22.5×10(-6)的预测值下，压电线性剪切模式与Sauerbrey方程的一致性是相似的，但对于12.7×10(-6)的二氧化硅器件的径向剪切模式则不符合。在吸附蛋白质的声学指纹图谱方面，讨论了平面线圈的宽频带激发和声学模式的选择所产生的机会。(C)2004爱思唯尔B.V.保留所有权利。
A transducer format that replaces the electrode of an acoustic resonator with a planar spiral coil is used to extract multifrequency spectral information from adsorbed protein films. Both amorphous silica and crystalline piezoelectric resonators are driven to resonance by forces induced across an air gap by magnetic direct generation and piezoelectric excitation induced by the electromagnetic field of the coil. Inspection of the harmonic frequencies between 6 MHz and 0.6 GHz indicates that the response of these two resonator types is described by different families of shear acoustic standing waves, with similar acoustic features to the quartz crystal microbalance. Exposure of the devices to protein solutions results in reproducible shifts of their harmonic frequencies, up to a maximum of 15 kHz and increasing linearly with frequency and operating mode. The gradient, determined from the ratio of the frequency change to the operating frequency was determined as 21.5 x 10(-6) for the quartz device and 60.9 x 10(-6) for the silica device. Consistency with the Sauerbrey equation for the piezoelectric linear shear mode was comparable at a predicted value of 22.5 x 10(-6), but not for the radial shear mode of the silica device at 12.7 x 10(-6). Opportunities resulting from the wide bandwidth of the planar coil excitation and choice of acoustic mode are discussed with respect to acoustic fingerprinting of adsorbed proteins. (C) 2004 Elsevier B.V. All rights reserved.