How dormant cancer persists and reawakens.
How dormant cancer persists and reawakens.
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DOI：
10.1126/science.aav0191
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发表时间：
2018-09-28
期刊：
影响因子：
--
通讯作者：
Aguirre-Ghiso JA
中科院分区：
文献类型：
--
作者：
Aguirre-Ghiso JA
IV期癌症的治疗，当转移可通过常规成像方法检测到时，通常是我们防御这种致命疾病阶段的唯一策略。然而，这些病变的种子，即播散性癌细胞（DCC），在其生长之前可以长时间驻留在患者的器官中（1）。DCC被认为能够持续多年，因为它们解释来自宿主微环境的稳态信号，并通过进入持久的休眠状态作出反应，偶尔发生细胞分裂（1，2）。为了响应尚未完全识别的信号，休眠的DCC重新唤醒并生长成更大的病变。那么，为什么不在DCC处于休眠状态时更早进行干预呢？这提出了一个挑战，因为DCC休眠的生物学机制尚不清楚，也没有办法确定DCC是否处于休眠状态。然而，二十年的机械研究（1，2）和最近的工作Pommieret等人。(3)以及Albrengudal在本期的第1353页。(4)已经提供了重要的见解DCC休眠和苏醒，导致转移，这可能具有治疗意义的微环境控制。
Treatment of stage IV cancer, when metastases are detectable by conventional imaging methods, is commonly the only strategy we have to defend against this lethal stage of disease. However, the seeds of those lesions, the disseminated cancer cells (DCCs), can reside in a patient's organs for long periods before their outgrowth (1). DCCs are proposed to be able to persist for years because they interpret homeostatic signals from the host microenvironment and respond by entering a long-lasting dormant state, with occasional cell divisions (1,2). In response to signals not yet fully identified, dormant DCCs reawaken and grow into larger lesions. So why not intervene earlier when DCCs are dormant? This has presented a challenge because the biology of DCC dormancy was mechanistically unclear and there was no way to determine whether DCCs were dormant. However, two decades of mechanistic research (1,2) and recent work by Pommieret al.(3) and on page 1353 of this issue by Albrengueset al.(4) have provided important insights into the microenvironmental control of DCC dormancy and reawakening that leads to metastasis, which could have therapeutic implications.
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影响因子：
32.4
作者：
Agudo J;Park ES;Rose SA;Alibo E;Sweeney R;Dhainaut M;Kobayashi KS;Sachidanandam R;Baccarini A;Merad M;Brown BD
通讯作者：
Brown BD
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
64.8
作者：
Blanco, Sandra;Bandiera, Roberto;Popis, Martyna;Hussain, Shobbir;Lombard, Patrick;Aleksic, Jelena;Sajini, Abdulrahim;Tanna, Hinal;Cortes-Garrido, Rosana;Gkatza, Nikoletta;Dietmann, Sabine;Frye, Michaela
通讯作者：
Frye, Michaela
影响因子：
21.3
作者：
通讯作者：
--
DOI：
10.1073/pnas.1507294112
发表时间：
2015-12-29
影响因子：
11.1
作者：
El Rayes, Tina;Catena, Raul;Mittal, Vivek
通讯作者：
Mittal, Vivek