Correlations between diffusion-weighted imaging and breast cancer biomarkers
Correlations between diffusion-weighted imaging and breast cancer biomarkers
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DOI：
10.1007/s00330-012-2403-8
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发表时间：
2012-07-01
影响因子：
5.9
通讯作者：
Montemurro, Filippo
中科院分区：
文献类型：
--
作者：
Martincich, Laura;Deantoni, Veronica;Montemurro, Filippo
我们对190例接受动态增强磁共振成像（MRI）的乳腺癌患者进行了DWI检查，以评估DWI提供的表观扩散系数（ADC）是否随乳腺癌的生物学特征而变化。对于192个指数癌症中的每一个，我们研究了ADC与经典组织病理学和免疫组化乳腺肿瘤特征（大小、组织学类型、分级、雌激素受体[ER]和Ki-67表达、HER 2状态）之间的相关性。将ADC与固有亚型的免疫组织化学替代物（管腔A;管腔B; HER 2富集;三阴性）进行比较。相关性分析采用Mann-Whitney U和Kruskal-Wallis H检验，ADC值与ER阳性细胞百分比之间存在弱的统计学显著相关性（-0.168，P = 0.020）。ER阴性肿瘤的中位ADC值显著高于ER阳性肿瘤（1.110 vs 1.050 x 10 - 3 mm 2/s，P = 0.015）。HER 2富集肿瘤的中位ADC值最高（1.190 x 10 - 3 mm 2/s，范围0.950-2.090）。多重比较显示，该值显著高于管腔A（1.025 x 10（-3）mm（2）/s [0.700-1.340]，P = 0.004）和管腔B/HER 2阴性（1.060 x 10（-3）mm（2）/s [0.470-2.420]，P = 0.008）肿瘤。统计显著性趋势（P = 0.018）。ADC值根据肿瘤的生物学特征而显著变化，表明癌症的异质性影响成像参数。a Euro cent DWI可以识别乳腺肿瘤的生物学异质性。a Euro cent ADC值根据乳腺癌的生物学特征而显著变化。a Euro cent与其他类型相比，HER 2富集的肿瘤显示最高的ADC值中位数。了解乳腺肿瘤的生物学异质性可以改善影像学解释。
We evaluated whether the apparent diffusion coefficient (ADC) provided by diffusion-weighted imaging (DWI) varies according to biological features in breast cancer.DWI was performed in 190 patients undergoing dynamic contrast-enhanced magnetic resonance imaging (MRI) for local staging. For each of the 192 index cancers we studied the correlation between ADC and classical histopathological and immunohistochemical breast tumour features (size, histological type, grade, oestrogen receptor [ER] and Ki-67 expression, HER2 status). ADC was compared with immunohistochemical surrogates of the intrinsic subtypes (Luminal A; Luminal B; HER2-enriched; triple-negative). Correlations were analysed using the Mann-Whitney U and Kruskal-Wallis H tests.A weak, statistically significant correlation was observed between ADC values and the percentage of ER-positive cells (-0.168, P = 0.020). Median ADC values were significantly higher in ER-negative than in ER-positive tumours (1.110 vs 1.050 x 10(-3) mm(2)/s, P = 0.015). HER2-enriched tumours had the highest median ADC value (1.190 x 10(-3) mm(2)/s, range 0.950-2.090). Multiple comparisons showed that this value was significantly higher than that of Luminal A (1.025 x 10(-3) mm(2)/s [0.700-1.340], P = 0.004) and Luminal B/HER2-negative (1.060 x 10(-3) mm(2)/s [0.470-2.420], P = 0.008) tumours. A trend towards statistical significance (P = 0.018) was seen with Luminal B/HER2-positive tumours.ADC values vary significantly according to biological tumour features, suggesting that cancer heterogeneity influences imaging parameters.aEuro cent DWI may identify biological heterogeneity of breast neoplasms.aEuro cent ADC values vary significantly according to biological features of breast cancer.aEuro cent Compared with other types, HER2-enriched tumours show highest median ADC value.aEuro cent Knowledge of biological heterogeneity of breast neoplasm may improve imaging interpretation.