Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China.
Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China.
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健康男性口腔和生殖器人乳头瘤病毒感染的并发性：中国农村地区基于人群的横断面研究。
DOI：
10.1038/srep15637
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发表时间：
2015-10-27
影响因子：
4.6
通讯作者：
Ke Y
中科院分区：
文献类型：
--
作者：
Liu F;Hang D;Deng Q;Liu M;Xi L;He Z;Zhang C;Sun M;Liu Y;Li J;Pan Y;Ning T;Guo C;Liang Y;Xu R;Zhang L;Cai H;Ke Y
人乳头瘤病毒（HPV）感染是生殖器癌症的主要原因，也与青年男子口咽癌发病率的增加有关。关于健康个体中同时发生口腔和生殖器感染的情况知之甚少。同时采集2566名农村男性口腔和生殖器拭子脱落细胞。采用通用引物介导（SPF 1/GP 6+）PCR和测序方法，对2228例有效的口腔和生殖器标本（β-珠蛋白阳性）进行HPV检测。口腔HPV感染率为6.7%，外生殖器HPV感染率为16.9%。在43名男性（1.9%，43/2228）口腔生殖器共同感染，60.5%（26/43）窝藏在两个网站相同的HPV类型。生殖器感染男性的口腔HPV感染风险高于未感染男性（11.4% vs. 5.7%，调整后OR = 2.3，95% CI：1.6-3.4）。此外，一生中有多个性伴侣是口腔生殖器HPV合并感染的显著风险（调整后OR = 2.6，95% CI：1.0-7.0; 2个伴侣vs. 1个伴侣）。这些发现为进一步了解口腔HPV感染的自然史和传播动力学提供了基础。
Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected simultaneously from 2566 men in rural China. Using general primer-mediated (SPF1/GP6+) PCR and sequencing, HPV testing results were obtained from 2228 men with both valid oral and genital specimens (β-globin-positive). The prevalence of HPV infection was 6.7% in the oral cavity and 16.9% for the external genitalia. Among 43 men (1.9%, 43/2228) with oral-genital coinfection, 60.5% (26/43) harbored an identical HPV type at both sites. The risk of oral HPV infection was higher among men with genital infection than among uninfected men (11.4% vs. 5.7%, Adjusted OR = 2.3, 95% CI: 1.6–3.4). In addition, having multiple lifetime sexual partners was a significant risk for oral-genital HPV coinfection (Adjusted OR = 2.6, 95% CI: 1.0–7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection.