Efficacy of Multiple Micronutrients Fortified Milk Consumption on Iron Nutritional Status in Moroccan Schoolchildren.
Efficacy of Multiple Micronutrients Fortified Milk Consumption on Iron Nutritional Status in Moroccan Schoolchildren.
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DOI：
10.1155/2015/690954
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发表时间：
2015
影响因子：
2.2
通讯作者：
Aguenaou H
中科院分区：
文献类型：
--
作者：
El Menchawy I;El Hamdouchi A;El Kari K;Saeid N;Zahrou FE;Benajiba N;El Harchaoui I;El Mzibri M;El Haloui N;Aguenaou H
缺铁是摩洛哥一个主要的公共健康问题，主要是妇女和儿童。本文的目的是评估食用多种微量营养素（MMN）强化牛奶对生活在农村地区的摩洛哥学童铁状况的影响。从学校招募了195名7 ~ 9岁的儿童，分为两组：非强化组（NFG）每天饮用非强化超高温（UHT）牛奶，强化组（FG）每天饮用添加硫酸铁等多种微量营养素的超高温牛奶。在基线（T0）和9个月后（T9）采集血样。用Hemocue仪原位测定血红蛋白（Hb）；分别用ELISA和浊度法测定血清铁蛋白和C反应蛋白。当p值<0.05时，认为结果显著。在T9时，FG显示铁缺乏症从50.9%减少到37.2% （p = 0.037）。尽管缺铁性贫血的患病率很低（1.9%）；在我们的样本中，超过50%的儿童在基线时缺铁。食用强化牛奶使生活在摩洛哥高海拔农村地区的学童缺铁率降低了27%。临床试验注册。我们的研究已在泛非临床试验注册中心注册，识别号为PACTR201410000896410。
Iron deficiency constitutes a major public health problem in Morocco, mainly among women and children. The aim of our paper is to assess the efficacy of consumption of multiple micronutrients (MMN) fortified milk on iron status of Moroccan schoolchildren living in rural region. Children (N = 195), aged 7 to 9 y, were recruited from schools and divided into two groups: the nonfortified group (NFG) received daily a nonfortified Ultra-High-Temperature (UHT) milk and the fortified group received (FG) daily UHT milk fortified with multiple micronutrients including iron sulfate. Blood samples were collected at baseline (T0) and after 9 months (T9). Hemoglobin (Hb) was measured in situ by Hemocue device; ferritin and C Reactive Protein were assessed in serum using ELISA and nephelometry techniques, respectively. Results were considered significant when the p value was <0.05. At T9 FG showed a reduction of iron deficiency from 50.9% to 37.2% (p = 0.037). Despite the low prevalence of iron deficiency anemia (1.9%); more than 50% of children in our sample suffered from iron deficiency at baseline. The consumption of fortified milk reduced the prevalence of iron deficiency by 27% in schoolchildren living in high altitude rural region of Morocco. Clinical Trial Registration. Our study is registered in the Pan African Clinical Trial Registry with the identification number PACTR201410000896410.