A preliminary Study on the Effect of Head and Neck Chemoradiotherapy on Systematic Immunity
A preliminary Study on the Effect of Head and Neck Chemoradiotherapy on Systematic Immunity
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头颈放化疗对系统免疫影响的初步研究
DOI：
10.1177/1559325819884186
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发表时间：
2019-10-01
期刊：
影响因子：
2.5
通讯作者：
Guan, Jian
中科院分区：
文献类型：
--
作者：
Huang, Weiqiang;Fan, Yao;Guan, Jian
背景：本研究旨在探讨放化疗对头颈癌患者系统免疫功能的影响。方法：我们对接受同期放化疗(CCRT)、加或不加诱导化疗(IC)的患者进行了回顾性研究。分别于ICR前、CCRT前、后抽血检查。采用流式细胞仪和免疫比浊法进行检测。结果：2018年4月1日至2019年3月31日共纳入患者58例。免疫球蛋白(Ig)水平，包括免疫球蛋白(Ig)、免疫球蛋白(Ig)和免疫球蛋白(Ig)，分别在IC和CCRT后2~3周期下降。血清总溶血补体(CH50)水平在IC后升高(P<0.01)，但在CCRT后保持稳定。自然杀伤(NK)细胞在IC后降低(P<；.01)，在CCRT后增强(P<；.001)。CD_3~+、CD_4~+、CD_4~+、CD_3~+、CD_4~+、CD_4~+、CD_3~+、CD_IC和CCRT均能显著增加CD3(+)CD8(+)T细胞(P<；.001 vs P<；.01)。结论：放疗(RT)和化疗(CT)均可诱导免疫应答的双重效应。同步放化疗在IC诱导的基础上产生主动免疫反应，提示RT在动员免疫系统方面具有潜在的作用。
Background: This study was designed initially to explore the effect of chemoradiotherapy on patients diagnosed with head and neck cancer (HNC) with respect to the alteration of systematic immunity. Methods: We did a retrospective study enrolling patients received concurrent chemoradiotherapy (CCRT), with or without induction chemotherapy (IC). Blood tests were performed before IC, before and after CCRT. Flow cytometric analysis and turbidimetric inhibition immunoassay were used for detection. Results: A total number of 58 patients were included from April 1, 2018, to March 31, 2019. Levels of immunoglobulins (Ig), including IgA, IgG, and IgM, declined after 2 to 3 cycles of IC and CCRT, respectively. Serum level of total hemolytic complement (CH50) increased (P < .001) after IC, but kept stably post-CCRT. Natural killer (NK) cells decreased (P < .01) after IC and enhanced (P < .001) post-CCRT. The number of CD3(+)CD4(+) T cells got increased (P < .01) after IC and decreased (P < .001) post-CCRT. Consistently, both IC and CCRT induced the increase in CD3(+)CD8(+) T cells significantly (P < .001 vs P < .01). Conclusion: Both radiotherapy (RT) and chemotherapy (CT) induced dual effect of immune response. Concurrent chemoradiotherapy created an active immune response based on the effect induced by IC, suggesting that RT exerted a potential function on mobilizing immune system.