Bacterial lipids: powerful modifiers of the innate immune response.
Bacterial lipids: powerful modifiers of the innate immune response.
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DOI：
10.12688/f1000research.11388.1
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Ernst, Robert K
中科院分区：
文献类型：
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作者：
Chandler, Courtney E;Ernst, Robert K
先天免疫系统是对抗微生物病原体的第一道防线。宿主先天免疫反应可以通过被称为 Toll 样受体的特定宿主受体蛋白识别保守的非自身微生物特征分子来触发。对于细菌来说，许多分子触发因素驻留在或嵌入细菌膜上，即暴露于宿主环境的界面。脂质是膜中最丰富的成分，细菌拥有一组独特的脂质，可以启动或改变宿主的先天免疫反应。细菌脂蛋白、肽聚糖和外膜分子脂磷壁酸和脂多糖是宿主免疫系统的关键调节剂。这篇综述文章将重点介绍一些在细菌膜和先天免疫交叉点出现的研究。
The innate immune system serves as a first line of defense against microbial pathogens. The host innate immune response can be triggered by recognition of conserved non-self-microbial signature molecules by specific host receptor proteins called Toll-like receptors. For bacteria, many of these molecular triggers reside on or are embedded in the bacterial membrane, the interface exposed to the host environment. Lipids are the most abundant component of membranes, and bacteria possess a unique set of lipids that can initiate or modify the host innate immune response. Bacterial lipoproteins, peptidoglycan, and outer membrane molecules lipoteichoic acid and lipopolysaccharide are key modulators of the host immune system. This review article will highlight some of the research emerging at the crossroads of bacterial membranes and innate immunity.