EVIDENCE FOR A MONOCLONAL ORIGIN OF HUMAN ATHEROSCLEROTIC PLAQUES AND SOME IMPLICATIONS
EVIDENCE FOR A MONOCLONAL ORIGIN OF HUMAN ATHEROSCLEROTIC PLAQUES AND SOME IMPLICATIONS
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DOI：
10.1161/01.cir.50.4.650
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发表时间：
1974-01-01
期刊：
影响因子：
37.8
通讯作者：
BENDITT, EP
中科院分区：
文献类型：
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作者：
BENDITT, EP
发育良好的动脉粥样硬化病变下面有大量的脂肪，而胆固醇存在于这些脂肪碎片中。这些事实引起了早期研究人员对这种物质的关注，并导致了胆固醇是疾病演变过程中的一个主要因素的假设。在动物身上，饮食控制导致血液胆固醇水平升高，产生了表面上相似的损伤，这强化了这一假设。考虑到不同地域和种族人群中冠心病与膳食脂肪摄入量的明显关系，研究人员相信动脉粥样硬化的起源是“灌输”的概念，这让他们受到鼓舞。1人类动脉粥样硬化的主要病变是细胞增殖、纤维斑块，而构成病变的原始细胞是一种平滑肌细胞，这一事实并不严重。最近关于动脉粥样硬化发病机制的建议修改了旧的假设，将增殖部分包括在内。2-一种建议是脂蛋白，因为它们似乎是动脉中膜细胞的首选营养物质，通过受损的内皮输送超过通常数量的脂蛋白，刺激动脉壁细胞增殖。在这种和类似的配方中，假设中间层细胞本身就是增殖细胞。
WELL-DEVELOPED LESIONS of atherosclerosis have substantial amounts of lipid underlying them and cholesterol is present in this fatty debris. These facts fastened attention of early investigators on this substance and ledto the supposition that cholesterol is a major factor in the evolution of the disease process. This assumption was strengthened by the production, in animals, of superficially similar lesions by dietary manipulations causing increased levels of blood cholesterol. Taken together with the apparent relationship of coronary disease and dietary lipid intake in different geographical and ethnic groups, investigators have been encouraged in their belief in the" insudation" concept of the origin of atherosclerosis. 1There is no serious question of the fact that the main lesion of human atherosclerosis is a cellular proliferation, the fibrous plaque, and the prime cell comprising the lesion is a form of smooth muscle cell. Recent proposals concerning thepathogenesis of atherosclerosis have modified the older hypothesis to include the proliferative component." 2-One suggestion has been that lipoproteins, since they seem to be preferred nutrients for the arterial medial cells, by their delivery in excess of usual amounts through damaged endothelium, stimulate arterialwall cell proliferation. The assumption in this and similar formulations is that the medial cells, as such, are the proliferating cells.