Seroepidemiology and Risk Factors of Toxoplasma gondii Infection among the Newly Enrolled Undergraduates and Postgraduate Students in China.
Seroepidemiology and Risk Factors of Toxoplasma gondii Infection among the Newly Enrolled Undergraduates and Postgraduate Students in China.
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我国新生弓形虫感染血清流行病学及危险因素分析
DOI：
10.3389/fmicb.2017.02092
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发表时间：
2017
影响因子：
5.2
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Yang N;Wang D;Xing M;Li C;Li J;Wu A;Sang X;Feng Y;Jiang N;Chen Q
刚地弓形虫是一种专性细胞内人畜共患寄生虫，感染温血动物包括人类。以前的弓形虫感染血清学调查集中在不同职业和特殊群体的人群中，如屠宰场工人、艾滋病患者和孕妇。为探讨弓形虫感染对青年学生健康的潜在影响，对新入学的本科生和研究生弓形虫感染情况及相关危险因素进行调查。本研究共招募了来自中国不同地区的3569名新生（年龄范围：15- 37岁，中位年龄26岁）。采用改良凝集试验（MAT）检测血清中是否存在弓形虫特异性IgG。使用问卷收集有关弓形虫感染危险因素的信息。3569名参与者中65人（1.82%）经MAT检测弓形虫IgG抗体血清阳性（滴度≥1:20）。单因素logistic回归分析发现原发地理位置、农村生活、园艺或农业、饮用未煮沸水4个变量与弓形虫感染呈正相关，其中园艺或农业是弓形虫阳性的独立危险因素，为今后的研究和控制政策提供参考。
Toxoplasma gondii is an obligate intracellular zoonotic parasite, infecting warm-blood animals including humans. Previous serological surveys of T. gondii infection have focused on people of different occupations and special groups, such as slaughterhouse workers, AIDS patients and pregnant women. To investigate the potential impact of T. gondii infection on the health of young students, the prevalence of T. gondii infection and associated risk factors among the newly enrolled undergraduates and postgraduate students were investigated. A total of 3,569 newly enrolled students (age range: 15- to 37-years-old, median 26 years) from various regions of China were recruited in this study. The serum samples were tested for the presence of T. gondii specific IgG by the modified agglutination test (MAT). Questionnaires were used to collect information on risk factors for T. gondii infection. Sixty-five (1.82%) out of 3,569 participants were seropositive for IgG antibodies to T. gondii by MAT (titer≥1:20). Four variables were found to be positively associated with T. gondii infection, including primary geographical location, living in rural areas, gardening or agriculture, and drinking unboiled water by the univariate logistic regression, and only gardening or agriculture was the independent risk factor for T. gondii positivity by using multivariate logistic regression in this study, which may provide information to guide future research and control policies.